Bone Regenerating Knee Implants for Long Term Bone Health

NHS每年进行130，000次膝关节置换。由于人口老龄化及Covid-19造成的积压，需求不断增长。部分膝关节手术是增长最快的治疗方法，特别是在年轻患者中，他们变得不活跃，生产力和社会联系的风险更高，并且具有更严重的长期后果。尽管骨科植入物取得了进展，但目前固体钴铬合金植入物仍然是膝关节骨关节炎的金标准治疗。这种材料的一个主要缺点是，它会长期损害骨骼健康，导致骨丢失和植入物松动。现有的部分膝关节胫骨部件显示出良好的患者结局，但是，由于其由固体钴Chrome合金制成，因此会干扰骨的自然动态重塑。此外，30%的螺钉因松动而失效。这种植入物使70%的骨面积负荷不足，抑制骨生长，使翻修手术复杂化。我们的3D打印组件集成了我们独特的多孔结构，尸体和动物数据表明，该结构比传统植入物更好地保持骨负荷和健康。恢复生理负荷将刺激植入物周围的长期骨生长，并通过骨长入多孔植入物进行长期生物固定。我们的植入物将是第一个带有聚合物对聚合物关节面的部分膝关节置换术，它消除了过敏反应的风险。我们预计这种植入物将为NHS节省终身成本，更广泛地说，有助于保持年轻男性和女性的积极性，生产力，独立性和社会联系，随着年龄的增长，享受更多的工作时间和有价值的个人生活。就业机会是这样的，平均而言，关节炎患者的收入低于那些没有。此外，由于寻求预防性治疗的机会减少和公共部门等待时间较长，对较贫穷的患者来说，疾病的管理已被证明更加困难。部分膝关节置换术提供日间手术治疗和比全膝关节置换术更快的恢复。在护理点和长期来看，它们也更具成本效益。我们的植入物将通过降低并发症的风险来改善这一点。通过这种方式，我们的服务将有助于缩小最富有和最贫穷的人之间的差距，确保所有病人都能得到负担得起的及时治疗。

The NHS performs 130,000 knee replacements annually. Demand is growing due to our ageing population and backlog caused by Covid-19\. Partial knee surgery is the fastest growing treatment, particularly in young patients for whom the risk of becoming less active, productive and socially connected is higher and has more severe long term consequences. Despite advances in orthopaedic implants, at present solid cobalt-chrome implants remain the gold-standard treatment for knee osteoarthritis. A major drawback of this material is that it diminishes bone health in the long term which can lead to bone loss and implant loosening. Existing partial knee tibial components show good patient outcomes, however, they disturb bone's natural dynamic remodelling because they are made from solid Cobalt Chrome. Additionally, 30% of them fail by loosening. Such implants under-load 70% of the bone area and inhibit bone growth, complicating revision surgery. Our 3D printed components integrate our unique porous structure which cadaveric and animal data indicates maintains bone loading and health better than conventional implants. Restoring physiological loading will stimulate long term bone growth around the implant and long-term biologic fixation via bone ingrowth into the porous implant. Our implant will be the first partial knee replacement with a polymer-on-polymer articulating surface, which removes the risk of allergenic response.We foresee this implant saving on lifetime costs for the NHS and more broadly, helping to keep young men and women active, productive, independent and socially connected as they age -- enjoying added years in work and a rewarding personal life. Employment opportunities are such that on average patients with arthritis earn less than those without. Furthermore, management of the disease has proven significantly more difficult for poorer patients, due to reduced opportunity to seek preventative treatment and longer public sector wait times. Partial knee replacements offer day surgery treatment and faster recovery than total knee replacement. They are also more cost effective at the point of care and over the long term. Our implants will improve this upon this by reducing risk of complication. In this way, our service will help to narrow the gap between the experience of the richest and poorest by ensuring affordable and timely treatment for all patients.