Biostatistics Core

项目摘要 生物统计学核心将提供必要的及时和高质量的统计支持， 方案项目。生物统计支持将集中在三个具体目标上：1）为 设计，分析和适当的推断，从实验室和患者样本研究中进行的， 项目，2）应用最先进的统计工具，以获得对项目中创建的数据的更多见解 以及3）提供用于组合来自多个源的数据的支持。一般分析原则包括 验证假设的方法;通过消除已知的变异来源来提高精度，例如 实验到实验的可变性;控制多个假设检验;以及验证模型。的数据和 方案编制支助将提供合并来自多个来源的数据和将数据存档的专门知识， 数据分析的结果将被保存和复制。生物统计学支持对于 方案项目。生物统计学核心为研究人员提供了方便和有保证的访问， 允许生物统计学家专门研究项目领域的内容知识和适当的 统计方法。一个专门的核心提供及时和高质量的生物统计服务作为其重点。

PROJECT SUMMARY The Biostatistics Core will provide the timely and high-quality statistical support necessary for the success of the Program Project. The Biostatistical support will center on three specific aims: 1) provide support for the design, analysis and proper inference from the laboratory and patient sample studies conducted in the Projects, 2) apply state-of-the-art statistical tools to gain additional insights into data created in the Projects and 3) provide support for combining data from multiple sources. The general analysis principles include methods to validate assumptions; improve precision by removing known sources of variation, such as experiment to experiment variability; control for multiple hypothesis testing; and validate models. The data and programming support will provide expertise in merging data from multiple sources and archiving data to allow the results of data analyses to be preserved and reproduced. Biostatistics support is critical for the success of the Program Project. The Biostatistics Core provides easy and guaranteed access for investigators and also allows the biostatisticians to specialize in the Project areas regarding content knowledge and appropriate statistical methodology. A dedicated Core provides timely and high-quality biostatistical services as its focus.