Optimizing a Mindfulness-Based Intervention for Poor Sleep Quality During Pregnancy

项目摘要/摘要 睡眠质量差在怀孕期间非常普遍，并与许多 不利的产妇心理和健康后果。尽管如此，关于干预措施的研究有限 在怀孕期间改善睡眠。此外，先前的研究还没有针对导致 这一人群的睡眠质量较差，如不适和疼痛。基于正念的干预，例如 基于正念的分娩和育儿(MBCP)特别适合于改善心理 对不适和疼痛的反应，孕妇更喜欢非药物干预，因为 对副作用的担忧。然而，缺乏优化和评估正念的研究-- 以改善产前睡眠质量为基础的干预。为此，拟议的项目将优化MBCP以 提高产前睡眠质量(MBCP-PS)并进行中试。候选人将使用最先进的 体验抽样方法，以确定对夜间身体症状的心理反应 最有说服力的是怀孕期间睡眠质量差。基于这些发现和来自 在重点小组中，候选人将选择MBCP组成部分，以最大限度地影响已确定的目标。最后， 候选人将进行MBCP-PS与常规治疗的试点随机对照试验，以 调查安全性、可接受性、依从性和可行性，并检查发生变化的初步证据 夜间生理症状的心理反应，以及与睡眠质量的关系。调查结果将 为R61/R33应用提供初步数据，以进一步优化MBCP-PS并进行充分的 动力随机对照试验。建议以患者为中心的辅导式研究生涯发展 大奖(家长K23)在以下方面提供实质性的实践经验和培训：1)交付和研究 基于正念的干预和其他心身干预，2)以机制为重点的干预发展和 分析，3)妇女围产期健康，4)睡眠生理学、评估和干预。候选人 将在出色的研究环境中开展拟议的工作。她已经组装了一个 杰出的知名导师和专业顾问团队，在这些主题上拥有深厚的专业知识，以密切 指导她提出的项目，以及致力于她的职业发展的人。拟议的奖励将 为应聘者提供建立独立研究计划所需的深入经验 侧重于优化和评估以正念为基础的干预措施，以促进妇女健康 围产期围产期。

PROJECT SUMMARY/ABSTRACT Poor sleep quality is highly prevalent during pregnancy, and is associated with increased risk of numerous adverse maternal psychological and health outcomes. Despite this, there is limited research on interventions to improve sleep during pregnancy. Further, prior research has not targeted the unique factors contributing to poor sleep quality in this population, such as discomfort and pain. Mindfulness-based interventions, such as mindfulness-based childbirth and parenting (MBCP), are particularly well-suited to improve psychological responses to discomfort and pain, and pregnant women prefer non-pharmacological interventions due to concerns about side effects. However, there is a paucity of research optimizing and evaluating mindfulness- based interventions to improve prenatal sleep quality. To this end, the proposed project will optimize MBCP to improve prenatal sleep quality (MBCP-PS) and conduct pilot testing. The candidate will use state-of-the-art experience sampling methods to identify the psychological responses to nightly physical symptoms that are most robustly associated with poor sleep quality during pregnancy. Based on these findings and feedback from focus groups, the candidate will select MBCP components to maximally impact the identified targets. Finally, the candidate will conduct a pilot randomized controlled trial of MBCP-PS versus treatment as usual to investigate safety, acceptability, adherence, and feasibility, and examine preliminary evidence of change in psychological responses to nightly physical symptoms, and associations with sleep quality. Findings will provide preliminary data for an R61/R33 application to further optimize MBCP-PS and conduct an adequately powered randomized controlled trial. The proposed Mentored Patient-Oriented Research Career Development Award (Parent K23) provides substantive hands-on experiences and training in: 1) delivery and research of mindfulness-based and other mind-body interventions, 2) mechanism-focused intervention development and analysis, 3) women's perinatal health, and 4) sleep physiology, assessment, and intervention. The candidate will carry out the proposed work within an outstanding research environment. She has assembled an exceptional team of renowned mentors and specialized advisors with deep expertise on these topics to closely guide her proposed projects, and who are dedicated to her career development. The proposed award will provide the candidate with the in-depth experiences needed to establish an independent program of research focused on optimizing and evaluating mindfulness-based interventions for promoting women's health during the perinatal period.