Human Genome Data Algorithms to Analytics Core (HuGe DATA)

摘要：海量数据核 三个个性化医学科布雷研究项目(RPS)都与遗传学和基因组学密切相关 需要广泛的计算基础设施和领域专业知识的研究。UNLV具有计算性 内华达州个性化医学研究所(NIPM)提供的硬件，国家超级计算 中心(NSC)、Switch Communications和Intel Corp.然而，广泛的专业知识是杂乱无章的， 分散的，或不存在的，因此不能有效地支持这种遗传学和个性化医学 研究。应用基因组学分析需要一个综合的多学科团队，并为其他 Cobre用户组。这个团队对新的调查人员、飞行员获奖者和继任者至关重要 项目。基因组分析和测序管道(GAP)核心也需要这样的支持， 管理核心(AC)需要基于Web的条目、关系和图形数据库以及评估 算法。 人类基因组数据算法到分析(大数据)核心将拥有系统方面的专业知识 管理层。因此，它将安装、维护、配置、升级、保护和管理软件，特别是 版本控制和优化。庞大的数据核心将建立一个领域专家团队，与之合作 研究人员设计、分析和解释遗传、生物信息学和生物统计学结果。这支队伍将 支持多个用户群体的需求。科布雷有三名新的调查员RPS和12名飞行员的资金 授予项目的部分依据是其对研究核心的创造性使用。总而言之，这些 项目将为混合充值和共同出资的可持续发展模式提供临界质量。空调将会 使用海量数据管理、算法和分析评估性能和进度 数据核心。目标有三个：1)支持Cobre研究人员；2)为Cobre计划管理数据 以及3)支持GAP和管理核心。

ABSTRACT: HUGE DATA CORE The three personalized medicine COBRE research projects (RPs) all heavily involve genetics and genomics research that requires extensive computational infrastructure and domain expertise. UNLV has computational hardware available from the Nevada Institute of Personalized Medicine (NIPM), the National Supercomputing Center (NSC), SWITCH Communications, and Intel Corp. However, a broad range of expertise is disorganized, dispersed, or does not exist, and thus not effective for supporting this genetics and personalized medicine research. An integrated multi-disciplinary team is needed for applied genomics analysis and to serve other COBRE user groups. This team is critical for the new investigators, pilot grant awardees, and replacement projects. The Genomic Analysis and Sequencing Pipeline (GASP) core also needs such support, and the Administrative core (AC) requires web-based entry, relational and graphical databases, and assessment algorithms. The Human Genome Data Algorithms to Analytics (HuGe DAtA) core will have expertise in systems management. Thus, it will install, maintain, configure, upgrade, secure, and manage software, especially for version control and optimization. The HuGe DAtA core will build a team of domain experts to collaborate with investigators to design, analyze, and interpret genetic, bioinformatic, and biostatistical results. This team will support the needs of several user groups. The COBRE has three new investigator RPs and funding for 12 pilot projects to be awarded, in part, on the basis of their creative use of the research cores. Collectively, these projects will provide the critical mass for a hybrid recharge and co-funding sustainability model. The AC will assess performance and progress using data management, algorithms, and analysis provided by the HuGe DAtA core. The aims are threefold 1) Support COBRE researchers, 2) Manage data for the COBRE program and 3) Support the GASP and Administrative cores.