Children's Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology

摘要 儿童慈悲医院临床药理学、毒理学和治疗创新科 堪萨斯城(CMH)，提供最大、最多样化的儿科临床药理学博士后 美国的培训计划。它由20名教师组成，其中包括1)接受过过敏/交叉培训的临床医生。 哮喘/免疫学、行为医学、心脏病学、环境/职业健康、胃肠病学、 血液学/肿瘤学，传染病，母婴医学，新生儿学，肾脏病，护理学， 药剂学、康复医学和毒理学，以及有经验的基础/翻译科学家 在分析化学、遗传学、基因组学、体外生物转化和分子生物学方面。附属教职员工 在生物伦理学、生物信息学、健康结果和药学领域贡献更多专业知识- 流行病学。该计划在药物遗传学、药学和生物医学领域做出了重大贡献。 指标和早期临床试验设计。该计划结合了强大的说教和经验培训在 药物遗传学/基因组学、代谢组学、药物计量学、药物流行病学、药物开发、 以及负责任的研究行为。它还提供了专门针对儿科的独特选修机会 基于PBPK的建模和模拟(Simcyp/Certara)、儿科监管审查和批准(FDA)、 生物信息学(PharmGKB)、处方管理(CMH/Medicaid)和成人药理学(Mayo)。二 附属医学院提供的独立硕士课程完善了CMH的学术课程。 所有的教学都是由在各自学科领域拥有丰富研究经验的教师完成的。 学员参加该项目至少三年；临床药理学的头两年 与第二年和第三年的次级专业培训相结合，第三年致力于 临床药理学。在初级导师、高级导师和奖学金监督的指导下 委员会，研究员完成临床和翻译研究项目，出版几本出版物/ 发表演讲，竞争至少一项研究拨款，并制定向独立过渡的计划 在毕业之前。强大的评估战略不断保证质量，多样性得到以下支持 一项全面的招聘战略。自成立以来，CMH已培训了24名儿科临床医生。 药理学研究员(17名儿科医生，6名药剂师，1名护士；14名女性，2名非裔美国人，1名西班牙裔，1名 美洲原住民，3名亚洲人)，他们在团契期间总共发表了118项科学成果 演讲，准备了102篇同行评议的手稿，并在#年成功竞标超过1,500,000美元 校内和校外资金。该计划是美国仅有的三个临床药理学委员会之一 专门致力于儿科临床药理学的认可培训计划及其长期记录 卓越为申请者提供了无与伦比的学科培训。

Abstract The Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation at Children’s Mercy Hospital (CMH) in Kansas City, offers one of the largest, most diverse, Pediatric Clinical Pharmacology post-doctoral training programs in the U.S. It is constituted by 20 faculty including 1) clinicians cross-trained in Allergy/ Asthma/Immunology, Behavioral Medicine, Cardiology, Environmental/Occupational Health, Gastroenterology, Hematology/Oncology, Infectious Diseases, Maternal/Fetal Medicine, Neonatology, Nephrology, Nursing, Pharmacy, Rehabilitation Medicine, and Toxicology, along with 2) basic/translational scientists with experience in analytical chemistry, genetics, genomics, in vitro biotransformation, and molecular biology. Affiliated faculty contribute additional expertise in the areas of Bioethics, Bioinformatics, Health Outcomes, and Pharmaco- epidemiology. The program has made substantial contributions in the areas of pharmacogenetics, pharmaco- metrics, and early phase clinical trial design. The program combines robust didactic and experiential training in pharmacogenetics/genomics, metabolomics, pharmacometrics, pharmacoepidemiology, drug development, and the responsible conduct of research. It also offers unique elective opportunities dedicated to pediatric PBPK-based modeling and simulation (Simcyp/Certara), pediatric regulatory review and approval (FDA), bioinformatics (PharmGKB), Formulary management (CMH/Medicaid), and adult pharmacology (Mayo). Two independent Masters programs offered by affiliated medical schools round out the academic program at CMH. All teaching is accomplished by faculty with significant research experience in their respective subject areas. Trainees affiliate with the program for a minimum of three years; the first two years in Clinical Pharmacology are blended with the second and third years of their subspecialty training and their third year is dedicated to clinical pharmacology. Under the direction of a junior mentor, a senior mentor, and a scholarship oversight committee, fellows complete both a clinical and translational research project, produce several publications/ presentations, compete for a minimum of one research grant, and develop a plan to transition to independence prior to graduation. Quality is continually assured by a robust evaluation strategy and diversity is supported by a comprehensive recruitment strategy. Since its inception, the program at CMH has trained 24 pediatric clinical pharmacology fellows (17 pediatricians, 6 pharmacists, 1 nurse; 14 female, 2 African American, 1 Hispanic, 1 Native-American, 3 Asian) who during their fellowship period have collectively delivered 118 scientific presentations, prepared 102 peer-reviewed manuscripts and successfully competed for over $1,500,000 in intramural and extramural funding. The program is one of only three American Board of Clinical Pharmacology accredited training programs dedicated solely to Pediatric Clinical Pharmacology and its longstanding record of excellence provides applicants with unparalleled training in the discipline.