The influence of repetitive head impacts on motion perception

本应用程序的目的是确定重复头部撞击（RHIs）对动态视觉敏锐度（DVA）期间运动感知和动眼肌反应的持久影响。这个项目的具体目的是：(1)检查RHI在单个运动季节对眼动控制的影响；(2)RHI在单个运动季节后是否损害运动知觉？拟议的研究符合NINDS的使命，即寻求有关大脑的基本知识，并利用这些知识减轻神经系统疾病的负担。假设在单赛季的接触性运动中，RHIs的存在会导致追逐平滑增益、跳眼幅度和峰值跳眼速度的降低以及视觉敏锐度的下降。为了验证这些假设，该研究将建立一项观察性研究，包括评估眼动控制和适应性DVA任务的行为，从单赛季RHIs的前、中、后三个赛季，独立于运动相关脑震荡，与非RHIs对照组相比。来自RHIs和控制组的35名运动员将从一级学生运动员橄榄球运动员和非接触控制组中招募。如果参与者在单个运动赛季中被诊断出与运动相关的脑震荡，或者如果他们之前有神经系统疾病，他们将被排除在外。根据试验数据，随着时间的推移，RHI组的平滑追踪增益和跳变平均/峰值速度将受到影响。预计这将导致视觉敏锐度下降和视觉感知任务的行为表现受损。这个项目是创新的，因为人们对RHIs的后果知之甚少。该研究结果将首次评估运动感知是否因RHIs而改变，以及这种潜在的DVA损失是否是异常眼球运动的结果。此外，本研究将首次研究在RHIs存在下spem和扫视的特征。这些新的调查以前没有建立，应该进一步评估以了解RHIs的风险。

The objective of this application will be to determine the lasting consequences of repetitive head impacts (RHIs) on motion perception and oculomotor response during dynamic visual acuity (DVA). The specific aims of this project are to (1) examine the effect of RHI on oculomotor control over a single athletic season and (2) does RHIs impair motion perception after a single athletic season? The proposed research is consistent with NINDS’s mission to seek fundamental knowledge about the brain to use that knowledge to reduce the burden of neurological disease. It is hypothesized the presence of RHIs will result in smooth pursuit gain, saccadic magnitude and peak saccadic velocity decreases along with a loss of visual acuity during the DVA tasks over the single season of contact sports. To test these hypotheses, the proposed research will institute a observational study that involves assessing oculomotor control and behavior on adaptive DVA tasks from pre-, mid-, and post-season of a single season of RHIs, that are independent of a sport-related concussion, as compared to non-RHIs controls. Thirty-five athletes from both the RHIs and control group will be recruited from Division I student-athlete football players and non-contact controls. Participants will be excluded if they have a diagnosed sport-related concussion during the single athletic season or if they have a prior existing neurological condition. Based on the pilot data, it is expected to see impaired smooth pursuit gain and saccadic mean/peak velocity in the RHI group over time. It is predicted this will lead to visual acuity loss and impaired behavioral performance in visual perception tasks. This project is innovative as little is known regarding the consequence of RHIs. The findings will be the first to assess if motion perception is altered as a result of RHIs and whether this potential DVA loss is a result of abnormal eye movements. In addition, this study will be the first to examine the characteristics of SPEMs and saccades in the presence of RHIs. These novel investigations have not been previously established and should be further evaluated to understand the risk of RHIs.