ShEEP Request for an X-Ray Irradiation System

所要求的设备是一台X-RAD 320大室独立X射线系统， 精密X射线公司该设备将显着推进大型现有研究 VA研究人员的数量，使目前的研究在新的方向延伸，并促进 多个VA调查员之间的合作。辐照器具有内置功能， 对小动物进行X射线照射和生物发光成像。有 目前克利夫兰退伍军人医疗中心没有设备进行任何形式的辐射， 研究或小动物的生物发光成像。这种乐器将演奏大调 在克利夫兰退伍军人医疗中心现场进行退伍军人研究方面发挥作用， 目前是不可行的，只能在场外进行。获得辐照器将 大大加强克利夫兰退伍军人管理局在包括癌症在内的各个领域的研究工作 研究，神经学研究和SARS-COV 2研究。除了是唯一一个 一种将成像和辐射整合到单个设备中的仪器， 这台仪器的关键是它的安全性。不像放射性辐照器具有很大的安全性， 出于监管考虑，这种基于X射线的仪器安全可靠。克利夫兰VA 研究计划有4个主要和几个次要用户，他们的研究将显着 受到这一工具的影响。此外，预计目前这方面的可用性 现有的技术将有助于为其他当地退伍军人事务部研究人员培养新的方向。所有 用户拥有强大的VA和其他国家资金的跟踪记录，这将有助于支持 使用这台机器。PI将帮助领导监督和维护设备的工作， 培训其他用户。总的来说，购买X-RAD 320辐照器将填补一个主要的未满足 需要许多VA研究人员和促进未来的研究工作。

The requested equipment is an X-RAD 320 large chamber self-contained X-ray system from Precision X-ray Inc. This equipment would significantly advance the existing research of a large number of VA researchers, enable the extension of current studies in new directions and foster collaborations among multiple VA investigators. The irradiator has built in functionality to perform both X-ray irradiation as well as bioluminescent imaging of small animals. There is currently no equipment at the Cleveland VA Medical Center to perform irradiation of any sort for research studies or bioluminescent imaging of small animals. This instrument will play a major role in enabling VA research to be performed on site at the Cleveland VA Medical Center that currently is not feasible and can only be performed off site. Acquisition of the irradiator will greatly enhance Cleveland VA research efforts in a variety of fields including cancer research, neurological research and studies on SARS-COV2. In addition to being the only instrument that incorporates imaging and irradiation into a single device, a major advantage of this instrument is its safety. Unlike radioactive irradiators that have major safety and regulatory concerns, this X-ray based instrument is safe and reliable. The Cleveland VA research program has 4 Major and several minor users whose research will be significantly impacted by this instrument. In addition, it is expected that the availability of this currently unavailable technology will help foster new directions for other local VA researchers. All of the users have strong track records of VA and other national funding that will help support the use of this machine. The PI will help lead the efforts to supervise and maintain the equipment as well as train other users. Overall, the purchase of the X-RAD 320 irradiator will fill a major unmet need for many VA researchers and facilitate future research efforts.