CARE4Kids: Administrative Core

项目摘要/摘要--行政核心 脑震荡是一种创伤性脑损伤，每年影响数百万人，特别是青少年。而当 许多人康复了，大量受伤的年轻人继续发展为持续性脑震荡后症状(PPCS)， 并经历持续的疼痛、功能障碍和残疾。由于脑震荡的多变性和主观性 脑震荡后症状的性质，我们预测和分类发展PPCS的能力目前是 非常有限。研究表明，PPCS的特定模式可能与不同的潜在因素有关 病理生理学。CARE4无墙儿童中心(CWow)的主要目标是确定可测量的 生物标志物(血液测试、脑扫描、电活动等)这将有助于客观地预测和定义 不同类别的PPCS。CARE4Kids CWow管理核心的主要目标是 提供必要的领导、组织、培训和基础设施，以实现高效 与能够提供质量控制的指定中心协调6个临床数据采集点 并维护和存储数据。行政核心将为所有数据收集提供培训和监督 临床和生物措施。生物测量可能包括认知测试，脑电活动， 扫描大脑结构、血液或唾液中的分子、心血管测试和压力反应。这个 管理核心还将为CARE4Kids CWow制定指导方针，以监测资金、科学 查询、数据整理和共享以及成果传播。其他重要角色包括标准化 定义，制定一致的方法，并协调年度会议，以确保财团 一个开放的论坛，用于应对、共享信息和解决意料之外的挑战。这项工作的成果 将导致改进但客观的医学测试，帮助预测脑震荡患者的病情 PPCS面临的最大风险。通过定义PPCS风险人群的客观类别，将有可能更好地 提供医疗护理，还将导致未来新疗法的试验。

PROJECT SUMMARY/ABSTRACT - Administrative Core Concussion is a form of traumatic brain injury that affects millions annually, particularly adolescents. While many recover, a large number of injured youth go on to develop persistent post-concussive symptoms (PPCS), and experience ongoing pain, dysfunction and disability. Due to the variability of concussion and the subjective nature of post-concussive symptoms, our ability to predict and classify those who develop PPCS is currently very limited. Research suggests that specific patterns of PPCS may be linked to different underlying pathophysiology. The primary goal of the CARE4Kids Center Without Walls (CWOW) is to identify measurable biological markers (blood tests, brain scans, electrical activity, etc.) that will help objectively predict and define different categories of PPCS. The primary goal of the CARE4Kids CWOW Administrative Core is to provide the necessary leadership, organization, training and infrastructure to permit efficient coordination of 6 clinical data collection sites with designated centers able to provide quality control and maintain and store data. The Administrative Core will provide training and oversight for all data collection of clinical and biological measures. Biological measures may include cognitive tests, brain electrical activity, scans of brain structure, molecules in blood or saliva, cardiovascular testing and stress responses. The Administrative Core also will establish guidelines for the CARE4Kids CWOW to monitor funding, scientific inquiry, data curation and sharing, and dissemination of results. Other important roles include standardizing definitions, developing consistent methods and coordinating an annual meeting to ensure the consortium has an open forum to meet, share information and troubleshoot unanticipated challenges. The results of this work will lead to improved, but objective, medical tests that help predict which patients with concussions are at greatest risk for PPCS. By defining objective categories of those at risk for PPCS, it will be possible to better provide medical care, and will also lead to future trials for new treatments.