Hormones: Molecular Mechanism of Action and Functions

项目摘要/摘要 这项培训基金的长期目标是为学业成绩优异的学生提供支持和培训 内分泌学及相关学科的高积极性博士后和博士后研究人员 通过现代遗传学在器官、细胞、分子水平上处理激素生物学的方方面面 各种模式生物中的工具。我们的目标是为学员提供广泛的知识背景， 包括课程作业、实验专业知识、研讨会、授予手艺和职业建议。该计划 是由我们优秀的培训人员和哥伦比亚大学丰富的研究基础设施实施的。 培训教师是高度协作的，在探索 类固醇、维甲酸、甲状腺和多肽激素的作用机制及其旁分泌相互作用 与生长因子、细胞因子及重要信号转导通路和器官间相关 通讯。受训人员可以在模型生物和人类的不同实验系统中工作 研究对象。我们不断更新我们的培训人员，以反映内分泌学研究的发展趋势 以及不断变化的哥伦比亚大学教职员工基础。这项培训计划已经实施了42年， 在此期间，我们的实习生取得了突出的成就，其中许多人目前持有 NIH资助的终身教职跟踪一流学术机构的教师职位。在上一个周期(2015-2019年)， 共有19名独特的受训人员已得到或目前正在得到培训补助金的支助。这个 最近资助的学员在他们的研究项目中都非常有成效。所有以前的实习生 继续从事与科学相关的职业。我们的大多数博士后研究员都完成了个人研究 资助金。我们继续与我们的研究员合作，帮助他们在当前和未来的研究中取得成功 事业。总体而言，培训计划强调在学术、研究和职业方面的卓越表现 建议。此外，参加该计划还使学员从不同的学科了解实际情况。 在内分泌学方面的应用，并突出他们的研究的翻译方面。由于稳定的 随着对培训资助名额的需求不断增加，我们要求增加职位，以适应我们的高度 合格的申请者队伍。

Project Summary/Abstract The long standing goals of this training grant are to provide support and training to academically strong and highly motivated predoctoral and postdoctoral researchers in the field of endocrinology and related subjects dealing with all aspects of hormone biology at the organ, cellular, molecular levels through modern genetic tools in various model organisms. We aim to provide our trainees with a broad intellectual background that includes coursework, experimental expertise, seminars, grant craftsmanship and career advice. The program is implemented by our outstanding training faculty and the rich research infrastructure at Columbia University. The training faculty are highly collaborative and national and international leaders in research exploring the mechanisms of steroid, retinoid, thyroid and polypeptide hormones as well as the paracrine interactions associated with growth factors, cytokines and important signaling transduction pathways and inter-organ communications. The trainees can work in diverse experimental systems across model organisms and human subjects. We continually update our training faculty to reflect the evolving trends in research in endocrinology and the changing Columbia faculty base. This training program has been in effect for 42 years and the accomplishments of our trainees during this time have been outstanding, with many of them currently holding NIH funded tenure track faculty positions in premier academic institutions. During the past cycle (2015-2019), A total of 19 unique trainees have been supported or are currently being supported by the training grant. The recently funded trainees have all been extremely productive in their research programs. All previous trainees continue to pursue science related careers. Most of our postdoctoral fellows have attained individual research grants. We continue to work with our fellows to help them achieve success in their current and future research careers. Overall, the training program emphasizes excellence in scholarship and research and career advising. In addition, participation in the program exposes trainees from diverse disciplines to practical applications in endocrinology and highlights translational aspects of their research. Due to the steadily increasing demand for training grant slots, we are requesting additional positions to accommodate our highly qualified pool of applicants.