Administrative Core

摘要-行政核心 融合阳性腺泡状横纹肌肉瘤（ARMS）仍然是最致命但了解最少的癌症之一 童年的回忆尽管1993年鉴定出PAX 3-FOXO 1融合蛋白是一种关键的致癌驱动因子， ARMS，受影响儿童的治疗策略保持不变。因此，FusOnC 2的总体目标是 中心是通过全面研究PAX 3-FOXO 1融合蛋白在ARMS中的治疗作用， 鉴定PAX 3-FOXO 1的可药物化的辅助调节剂、调节剂和内在活性。为了支持这一点， 行政核心将提供领导、监督、协调、整合、传播和评估 并将其连接到NCI FusOnC 2联盟鉴于我们的多学科，多机构 这些活动将提高科学的严谨性，加速我们的集体进步。总体PI Corinne Linardic，MD，PhD和Christopher Counter，PhD将领导该核心，由执行委员会支持， 科学顾问委员会（SAB）和行政人员，包括经验丰富的中心管理员和 专业财务经理。Linardic博士和Counter博士以及执行委员会也将与 NCI项目官员、项目科学家和FusOnC 2联盟指导委员会关于中心 计划和方向。行政核心提出了以下具体目标：1）提供组织和 2）协调和加强中心各组成部分之间的互动; 3)提供财务管理，确保遵守财政和监管规定; 4）监测科学进展， 科学严谨性; 5）传播发现和合作; 6）建立内部和 外部审查。通过中心执行委员会的定期会议，核心将管理，协调， 整合项目和核心的科学活动，提供决策透明度， 促进参与FusOnC 2联盟的活动。除执行委员会会议外， 行政核心将协调“定量科学工作组”的会议， 跨项目数据审查和透明度，并识别和减轻风险，包括需要的分析 由他人确认或复制，从而有助于确保可重复性。与FusOnC 2结合使用 联合会指导委员会，行政核心将制定和执行及时数据政策 分享和出版。行政核心将作为我们中心活动的“枢纽”， 进步和提高严谨性，并作为与其他FusOnC 2中心的联系， 联合会的合作项目。透过外展计划，核心计划将培育学员的职业发展 促进数据和资源共享。本中心致力于全面参与FusOnC 2联盟 活动，研究团队欢迎有机会应用雄心勃勃的新技术和方法 来解决融合蛋白引发的癌症问题。

ABSTRACT – Administrative Core Fusion-positive alveolar rhabdomyosarcoma (ARMS) remains one of the most fatal but least understood cancers of childhood. Despite the 1993 identification of the PAX3-FOXO1 fusion protein as a key oncogenic driver of ARMS, treatment strategies for affected children remain unchanged. Thus the overarching goal of this FusOnC2 Center is to advance the therapeutic tractability of the PAX3-FOXO1 fusion protein in ARMS by comprehensively identifying the druggable co-regulators, modulators, and intrinsic activities of PAX3-FOXO1. In support of this, the Administrative Core will provide leadership, oversight, coordination, integration, dissemination and evaluation for the Center and connect it to the NCI FusOnC2 Consortium. Given our multi-disciplinary, multi-institutional team, these activities will enhance scientific rigor and accelerate our collective progress. Overall PIs Corinne Linardic, MD, PhD, and Christopher Counter, PhD will lead this Core, supported by the Executive Committee, Scientific Advisory Board (SAB), and administrative staff, including an experienced Center Administrator and an expert Financial Manager. Drs. Linardic and Counter, and the Executive Committee also will work closely with the NCI Program Officer, Project Scientist, and FusOnC2 Consortium Steering Committee regarding Center plans and direction. The Administrative Core proposes the following Specific Aims: 1) Provide organizational and logistical support for component activities; 2) Coordinate and enhance interactions among Center components; 3) Provide financial management and ensure fiscal and regulatory compliance; 4) Monitor scientific progress and scientific rigor; 5) Disseminate discoveries and collaborate; and 6) Establish mechanisms for internal and external review. Through the Center Executive Committee’s regular meetings, the Core will manage, coordinate, and integrate scientific activities across the Projects and Cores, provide transparency in decision-making, and facilitate participation in FusOnC2 Consortium activities. In addition to the Executive Committee meetings, the Administrative Core will coordinate meetings of a “Quantitative Sciences Working Group” to provide a layer of cross-Project data review and transparency, and to identify and ameliorate risks, including analyses that need to be confirmed or replicated by others, thus helping to ensure reproducibility. In conjunction with the FusOnC2 Consortium Steering Committee, the Administrative Core will develop and implement policies for timely data sharing and publication. The Administrative Core will serve as the “hub” for our Center’s activities to accelerate progress and enhance rigor, and as the link to other FusOnC2 Centers for development and conduct of collaborative Consortium projects. Through our outreach plan, the Core will nurture trainees’ career development and promote data and resource sharing. This Center is committed to full participation in FusOnC2 Consortium activities, and the research team welcomes this opportunity to apply ambitious new technologies and approaches to solve the problem of fusion protein-fueled cancers.