North American AIDS Cohorts Collaboration on Research and Design (NAACCORD) Renewal

北美艾滋病队列研究和设计合作组织（NA-ACCORD）是来自美国和加拿大的20多个学术和社区前瞻性艾滋病毒研究队列的合作组织。它是北美最大的艾滋病毒队列合作，并已被证明是美国艾滋病毒流行的代表（根据CDC艾滋病毒监测报告）。NA-ACCORD合作研究者可以使用以下数据回答紧急COVID-19问题：1）大规模艾滋病毒感染者（PWH）和非艾滋病毒感染者（PWOH）队列的现有数据; 2）新建立的接受SARS-Cov-2检测的人群（无论检测结果如何），每天招募参与者。NA-ACCORD研究人员将合作共享数据收集工具、识别COVID-19疾病的算法和分析方法，以加快对多个数据源中的紧急问题的回答，并了解结果的异质性。 为了回答紧急的COVID-19问题，此补充将支持：1）组建一支由经验丰富的传染病流行病学家和精通纵向研究设计的临床医生组成的团队，他们专注于回答紧急COVID-19问题，并了解不同队列回答相同问题所导致的结果异质性2）使用EHR数据建立3个纵向COVID-19临床队列的基本步骤3）数据管理和分析专业知识，具体到传染病的深刻健康影响，使用来自临床的数据（即主要是EHR数据）和间隔队列研究4）建立COVID-19调查、受调查人员（PUI）表格和现有队列研究的其他文件表格库，并为NAACCORD队列提供基于RedCap的调查，以期待未来的合作研究5）基于EHR的COVID算法的开发和共享-19并促进与其他致力于COVID-19通用数据模型的团体的合作

The North American – AIDS Cohort Collaboration on Research and Design (NA-ACCORD) is a collaboration of >20 academic and community-based prospective HIV research cohorts from the United States and Canada. It is the largest collaboration of HIV cohorts in North America and has been shown to be representative of the US HIV epidemic (according to CDC HIV Surveillance reports). Urgent COVID-19 questions can be answered by NA-ACCORD co-investigators using: 1) existing data in large-scale cohorts of people with (PWH) and without HIV (PWOH); and 2) newly established cohorts of people who have been tested for SARS-Cov-2 (regardless of the test result), which are enrolling participants every day. NA-ACCORD investigators will work collaboratively to share data collection instruments, algorithms for identifying COVID-19 disease, and analytic approaches to expedite answers to urgent questions in multiple data sources and understand the heterogeneity in findings. To answer urgent COVID-19 questions, this supplement will support: 1) assembling a team of experienced infectious disease epidemiologists and clinicians versed in longitudinal study design who are focused on answering urgent COVID-19 and understand heterogeneity in findings resulting from the same question being answered in different cohorts 2) the foundational steps to establishing 3 longitudinal COVID-19 clinical cohorts using EHR data 3) data management and analytic expertise specific to the profound health impacts of infectious disease using data from clinical (i.e. primarily EHR data) and interval cohort studies 4) establishing a library of COVID-19 surveys, person under investigation (PUI) forms, and other documentation forms from existing cohort studies, and providing a RedCap-based survey to NAACCORD cohorts in anticipation of future collaborative research 5) the development and sharing of EHR-based algorithms for COVID-19 and facilitating engagement with other groups working on common data models for COVID-19