Administrative Core

摘要 行政核心将负责实施充实方案，并将协调和整合 组织学、生物化学和分子成像（HBMI）以及生物力学、生物材料和 多模态组织成像（B2 MTI）核心，以确保罗切斯特资源的进展- 本中心的骨，肌肉和骨科研究（ROCSTARR）的有效方式。 核心用户委员会，URMC共享资源实验室和设施，以及会议 行政核心的结构是组织沟通的关键要素， ROCSTARR研究人员之间的合作，以及与该中心的其他教师， 肌肉骨骼研究（CMSR）和大学内的合作部门和中心。 行政核心中的联合主任、导师、顾问和工作人员的活动将密切 由核心用户委员会监督，该委员会由初级到中级职业教师和学员组成， 并在我们的2019年肌肉骨骼研究中心（CMSR）5年战略计划中成立， 提供直接反馈。这些活动将由共同主任每周正式审查， 具体目标如下。1)维护最先进的基于资源的核心， 基础科学，转化和临床骨，肌肉和骨科研究;并利用这些 以具有成本效益的方式整合资源，以加快发现和临床转化的步伐。2)到 继续促进我们高度合作的环境，将基础研究转化为临床试验， 并扩大我们的外展活动，将新的重点放在代表性不足的少数群体上，以促进 利用P30核心提供的资源进行新的外部合作， 肌肉骨骼研究基地在URMC，国内和国际。3)为了增加我们的试点补助金 每年10万美元至13万美元的计划，并设立一个新的平行发现基金， 指导核心将迅速分配小额赠款高达5000美元。我们亦会加强 除了这些试点赠款，威廉F。Neuman客座教授系列， 年度肌肉骨骼研究研讨会，通过扩大社区和促进创新 骨骼、肌肉和整形外科研究。4)为了保持我们的临床翻译分- 管理人类受试者研究服务的核心， 临床转化科学研究所，加强肌肉骨骼基础科学的转化， 临床应用，并发展协作网络，新的重点是大数据科学，外科 结果和人口健康研究。和，5）扩大我们非常成功的指导 计划，这有利于我们的新的/早期阶段的研究人员到NIH R 01资助的进步 PI和国家领导地位，并执行最高标准的科学严谨的回应 国家卫生研究院的计划，以提高可重复性。实现这些目标将加速和加强 生产力和建立肌肉骨骼研究工作队伍在URMC和超越。

Abstract The Administrative Core will run the Enrichment Program, and will coordinate and integrate the Histology, Biochemistry and Molecular Imaging (HBMI) and the Biomechanics, Biomaterials and Multimodal Tissue Imaging (B2MTI) Cores, in order to ensure progress of the Rochester Resource- based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) in an efficient manner. The Core Users Committees, the URMC Shared Resource Laboratories & Facilities, and meeting structure of the Administrative Core are key elements that organize the communication and collaboration among the ROCSTARR investigators, as well as with other faculty in the Center for Musculoskeletal Research (CMSR) and collaborating Departments and Centers within the University. The activities of the Co-Directors, Mentors, Advisors, and staff in the Administrative Core will be tightly monitored by the Core Users Committee, which is made up of junior to mid-career faculty and trainees, and was established in our 2019 Center for Musculoskeletal Research (CMSR) 5-year Strategic Plan to provide direct feedback. These activities, which will be formally reviewed weekly by the Co-Directors, are embodied by the following Specific Aims. 1) To maintain state-of-the-art resource-based Cores for basic science, translational and clinical bone, muscle & orthopaedic research; and utilize these resources in a cost-effective manner to accelerate the pace of discovery and clinical translation. 2) To continue to foster our highly collaborative environment that translates basic research into clinical trials, and to expand our outreach activities with a new focus on underrepresented minorities, to promote the use of the resources offered by the P30 Core to new external collaborations that will grow our musculoskeletal research base at URMC, nationally and internationally. 3) To grow our Pilot Grant Program from $100,000 to $130,000 per year with a new parallel Discovery Fund, with which the Mentoring Core will expeditiously allocate small grants up to $5,000. We will also enhance our Enrichment Programs beyond these Pilot Grants, the William F. Neuman Visiting Professor series, and Annual Musculoskeletal Research Symposium, by expanding the community and promoting innovative research in bone, muscle and orthopaedic research. 4) To maintain our Clinical-Translational Sub- Core that administers human subject research services leveraging and customizing resources from the Clinical-Translational Science Institute, to enhance the translation of musculoskeletal basic science to clinical application, and grow collaborative networks with a new emphasis on Big Data science, surgical outcomes and population health research. And, 5) To expand our highly successful Mentoring Program, which facilitates the advancement of our New/Early Stage Investigators to NIH R01 funded PIs and national leadership status, and implements the highest standards of scientific rigor in response to NIH’s plan to enhance reproducibility. Execution of these aims will accelerate and enhance the productivity and establishment of the musculoskeletal research work force at URMC and beyond.