Switchable and stereocontrolled photoredox catalysis

该项目旨在开发新的催化合成反应，以便在温和条件下使用可见光快速和更直接地功能化有机化合物。综合实验和计算方法将用于设计有效的可见光光催化剂，该催化剂保留了标准光氧化还原催化的优点，但增加了拦截和控制活性中间体的能力。这将使光氧化还原反应中的立体化学控制成为可能——这是标准催化剂无法做到的——并建立其他有用的合成转化。这些策略将使制备有价值的有机分子变得更容易——高效、安全、经济。

This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in situ. This will enable the control of stereochemistry in photoredox reactions – not possible with standard catalysts - and establish other useful synthetic transformations. These strategies will make it easier to prepare valuable classes of organic molecules – efficiently, safely, and cost-effectively.