Core C Analysis and Modeling --Davenport UNSW

分析和建模核心将通过以下方式支持该计划：1）开发最佳研究设计， 用于测量和比较S（H）IV从接受以下治疗的猴子的潜伏期再激活的建模方法： bNAbs或FTY-720; 2）开发用于识别SIV再激活的早期来源的分析方法， 分析处理中断（ATI）后水库“重新播种”的量化; 3）分析免疫 ATI和反弹期间的动力学和病毒选择;以及4）协调和整合 项目1和2，并为更广泛的研究社区提供数据和分析工具。AMC将 与所有项目和子项目紧密结合，以确保实验和动物研究 设计和进行，以最大限度地提高我们的能力，剖析病毒重新激活的动态和影响， 抗体和细胞迁移。AMC成员将与项目负责人密切合作， 开发最佳研究设计，包括采样时间和测序深度等参数 必需的.

The Analysis and Modeling Core will support the Program by 1) developing optimal study design and modeling methods for measuring and comparing S(H)IV reactivation from latency in monkeys treated with bNAbs or FTY-720; 2) developing analytical approaches for identifying early sources of SIV reactivation and quantification of reservoir ‘re-seeding’ following analytical treatment interruption (ATI); 3) analyzing immune dynamics and viral selection during ATI and rebound; and 4) coordinating and integrating analysis between Projects 1 & 2, and providing data and analysis tools to the broader research community. The AMC will be integrated closely within all projects and sub-projects to ensure that the experimental and animal research is designed and conducted to maximize our ability to dissect the dynamics of viral reactivation and the impact of antibodies and cell migration on this. Members of the AMC will work closely with the Project leaders to develop optimal study designs, including parameters such as sampling times and depth of sequencing required.