SEER-LINKED PEDIATRIC CANCER WHOLE SLIDE IMAGING PILOT, LOUISIANA STATE UNIV HEALTH SCIENCES CONTRACT HHSN261201800007I, POP 8/17/2020-8/16/2021

项目摘要：LTR已经在所有病理实验室(除了那些有小型癌症病例的实验室)实施了电子病理学(e-Path)报告，覆盖了路易斯安那州95%以上的显微镜确诊癌症病例。我们还颁布了立法规则，授权LTR获取肿瘤组织用于生物医学研究。通过NCI资助的SEER链接虚拟组织仓库(VTR)研究和支持其他生物标本研究，我们增强了我们的基础设施，并练习了作为生物标本研究的诚实经纪人的能力，例如获得必要的监管批准，检索所需的肿瘤组织，并使用癌症数据对其进行注释。我们渴望抓住这一新机会，进一步改善和扩大我们的能力，以支持自动数字图像分析算法的开发，以帮助病理学家进行组织形态评估，并检查提取的显微特征与疾病结果和治疗反应之间的关联。

Project Abstract: The LTR has implemented electronic pathology (e-path) reporting at all pathology laboratories (except those with small cancer cases), covering over 95% of microscopically confirmed Louisiana cancer cases. We have also promulgated the legislative rules authorizing LTR to obtain tumor tissues for biospecimen research. Through the NCI-funded SEER-Linked Virtual Tissue Repository (VTR) study and supporting other biospecimen research, we have enhanced our infrastructures and exercised the ability to serve as an honest broker for biospecimen research, such as obtaining the necessary regulatory approval, retrieving required tumor tissues, and annotating them with cancer data. We are eager to take on this new opportunity to improve and expand further our capacity to support the development of automated digital image analysis algorithms to aid histomorphologic assessment by pathologists and examine associations between extracted microscopic features and disease outcome and response to treatments.