NCI SEER-LINKED PEDIATRIC WHOLE SLIDE IMAGING (POP: 8/17/2020 - 8/16/2021)

项目摘要：高质量数字扫描仪的发展使得从癌症患者的组织学材料中产生苏木精-伊红(H&E)载玻片的详细图像成为可能。新兴的新信息学技术也使开发机器学习模型成为可能，以从数字化的幻灯片中提取额外的重要特征，如肿瘤浸润性淋巴细胞、描绘肿瘤区域和识别核分割。肯塔基州癌症注册中心的虚拟组织存储库(VTR)拥有从全州各地的病理实验室获取特定患者群体的H&E幻灯片、将这些幻灯片数字化、将匿名数字化图像提交给国家癌症研究所(NCI)进行研究以及将原始幻灯片返回给贡献的病理实验室的经验。

Project Abstract: The development of high-quality digital scanners has made it possible to produce detailed images of hematoxylin and eosin (H&E) slides from cancer patient histological material. Emerging new informatics technologies also make it possible to develop machine learned models to extract additional important features from the digitized slides such as tumor infiltrating lymphocytes, delineating tumor regions and identifying nuclear segmentation. The Kentucky Cancer Registry’s Virtual Tissue Repository (VTR) has experience obtaining the H&E slides for specific patient populations from pathology labs across the state, having these slides digitized, submitting the anonymized digitized images to the National Cancer Institute (NCI) for research, and returning the original slides to the contributing pathology labs.