CHROME - Circadian Hypertension Rhythm Optimization Management Environment

CHROME背后的理念侧重于自我驱动的医疗保健。我们对CHROME的愿景是提供一个单一的解决方案，通过使用现有的CE标记的贴式设备来测量ECG，从而建立与昼夜节律一致的血压。主要目标是建立与昼夜节律一致的血压，这样我们就可以在不使用充气袖带的情况下，根据7天内通常60,480个读数提供个性化的高血压管理评分。主要关注的领域是改进我们的算法，并开发一个应用程序，该应用程序可以在现有的贴贴式补丁硬件和智能手机之间进行接口，可用于记录ECG数据，并执行我们的算法将ECG信号转换为近实时的收缩压/舒张压读数，从而为设备的佩戴者提供接近真实的血压，而无需充气袖带。这是一种创新，因为它允许我们使用现有的CE标记的硬件，具有蓝牙功能，但尚未被利用，来创建扩展现有可穿戴设备的可用性的东西。我们使用市面上最轻、防雨的贴贴式心电贴片，实时采集心电信号，并将10秒时间序列的心电信号转换为血压。对于用户来说，这代表着他们的血压数据的可访问性发生了相当大的变化，使他们能够看到他们的血压随时间的变化趋势，与他们的昼夜节律保持一致。这对于个性化医疗具有巨大的潜力，因为你第一次可以看到药物化合物对心电图和更重要的血压的影响。这可能是第一个消费者系统，使用户能够了解服用高血压管理药物（如β受体阻滞剂或ACE抑制剂）的性能影响和时间反应。人们讨厌佩戴可充气的血压袖带，CHROME弥补了不可接受的血压袖带与可接受的智能手机健康监测之间的差距。CHROME是一个提案，将帮助我们发展我们的想法和我们的业务，创造一个新的收入来源，提供证据，使我们的市场，并帮助昼夜动力学有限公司的资金和商业化计划。该项目有助于我们的商业道路，并为公司的知识产权潜力提供证据。

The idea behind CHROME focuses on self-driven healthcare.Our vision for CHROME is to provide a single solution for the establishment of Blood Pressure, aligned to Circadian Rhythm, through the use of an existing CE marked stick-on device that measures ECG.The key objectives are to establish the Blood Pressure aligned to the Circadian Rhythm, such that we can provide a personalised Hypertension management score based on typically 60,480 readings taken over a 7 day period, without the use of an inflatable cuff.The main area of focus is to refine our algorithm and to develop an app that interfaces between the existing stick-on patches hardware and a smartphone that can be used to record the ECG data and execute our algorithm to convert the ECG signal into a systolic/diastolic Blood Pressure reading in near-real time, giving the wearer of the device a near-real Blood Pressure, without the need for an inflatable cuff.This is innovative as it allows us to use an existing CE marked piece of hardware, that has Bluetooth functionality, but which has not been exploited, to create something that extends the usability of an existing wearable device.We use an existing stick-on ECG patch, the lightest, showerproof, device on the market, take the ECG signal from this in real-time and convert a 10 second time sequence of ECG signal into Blood Pressure.For the user, this represents a considerable step change in the accessibility of their Blood Pressure data, allowing them to see their BP trended over time, aligned to their Circadian Rhythm.This has enormous potential for personalised medicine as for the first time you can see the effect on pharmacological compounds on the both the ECG and more importantly the Blood Pressure. This is perhaps the first consumer system that allows users to understand the performance effects and time-response to the ingestion of Hypertension management drugs such as Beta-blockers or ACE inhibitors.People hate wearing inflatable Blood Pressure cuffs, CHROME bridges the gap between the unacceptability of Blood Pressure cuffs with the acceptability of smartphone health monitoring.CHROME is a proposal that will help us develop both our idea and our business, create a new revenue stream, provide evidence and enable our market, and help with the funding and commercialisation plans for Circadian Dynamics Limited.The project assists our commercial path and generates evidence of the potential for the company's IP.