Purchase of a high-density electroencephalography (EEG) and neuromodulation system for use in an institutional core facility

摘要 这项拨款申请要求资助购买高密度脑电图（EEG）系统 住在波士顿儿童医院的人类神经生理学中心EEG系统提供了 最先进的技术，将允许研究人员在实验设计的灵活性，以纳入事件相关的 电位、磁共振成像（MRI）联合采集、经颅磁刺激（TMS） 应用和生理学共配准到高密度EEG收集中。所选设备已 针对儿科人群的EEG生物标志物收集进行了优化，包括婴儿、幼儿、 神经发育迟缓和神经精神病学。重要的是，设备将位于 在一个核心设施内，配备了设计、收集和分析EEG数据的专家，使用户能够 获得与NIMH资助的广泛研究目标相关的有影响力的结果。 由于EEG技术的能力，EEG被纳入越来越多的研究中 以产生反映敏感人群神经功能和连接性的高质量数据。的生物标志物 疾病状态、免疫学、分层和治疗反应已经在一些 神经精神障碍，包括自闭症谱系障碍、ADHD、精神障碍和 抑郁/焦虑。此外，正在进行大量的EEG研究，专门用于治疗 适应症与生理指标（心率、皮肤电反应）、TMS和MRI神经功能相结合， 反馈然而，这些研究目标的实现依赖于标准化的， 可重现的数据，这取决于具有内置验证功能的高质量设备， 技术专长。为此，在核心环境中提供这里概述的最先进的设备 使基于EEG的生物标志物和治疗应用的整合成为可能， 改善心理健康的成果。

ABSTRACT This grant application requests funding for the purchase of a high-density electroencephalography (EEG) system to reside in the Human Neurophysiology Core at Boston Children's Hospital. The EEG system offers state-of- the-art technology that will allow investigators flexibility in experimental design to incorporate event related potentials, magnetic resonance imaging (MRI) co-acquisition, transcranial magnetic stimulation (TMS) application and physiology co-registering into high density EEG collection. The equipment selected has been optimized for EEG biomarker collection in pediatric populations, including infants, young children, children with neurodevelopmental delays and neuropsychiatric symptomatology. Importantly, the equipment will be located within a Core facility staffed with experts in the design, collection and analysis of EEG data enabling users to obtain impactful results related to a broad array of NIMH funded research aims. EEG is being incorporated into an increasing number of research studies due to the capacity of this technique to yield high quality data reflecting neural function and connectivity from sensitive populations. Biomarkers of disease state, prognostics, stratification and treatment response have been identified in a number of neuropsychiatric disorders including autism spectrum disorder, ADHD, psychotic disorders and depression/anxiety. Furthermore, considerable EEG research is being undertaken specifically for therapeutic indications in combination with physiological measures (heart rate, galvanic skin response), TMS and MRI neuro- feedback. The realization of these research goals, however, is dependent on the collection of standardized, reproducible data, which is dependent on high quality equipment with built-in validation capabilities and deep technical expertise. To this end, availability of the state-of-the art equipment outlined here within a core setting makes incorporation of EEG based biomarkers and therapeutic applications possible for all investigators focused on improving mental health outcomes.