Purchase of a high-density electroencephalography (EEG) and neuromodulation system for use in an institutional core facility

摘要 这项拨款申请要求为购买高密度脑电(EEG)系统提供资金 住在波士顿儿童医院的人类神经生理学中心。EEG系统提供了状态- 最先进的技术，将允许研究人员在实验设计中灵活地纳入与事件相关的内容 电位，磁共振成像(MRI)共采集，经颅磁刺激(TMS) 在高密度脑电采集中的应用和生理协同配准。所选设备已被 针对儿科人群的脑电生物标记物收集进行了优化，包括婴儿、幼儿、患有 神经发育迟缓和神经精神症状学。重要的是，这些设备将被定位 在核心设施内，配备了设计、收集和分析脑电数据的专家，使用户能够 获得与NIMH资助的一系列研究目标相关的有影响力的结果。 由于这项技术的能力，脑电正在被纳入越来越多的研究研究中 从敏感人群中产生反映神经功能和连接性的高质量数据。生物标记物 疾病状态、预后、分层和治疗反应已在许多 神经精神障碍，包括自闭症谱系障碍，ADHD，精神障碍和 抑郁/焦虑。此外，大量的脑电研究正在进行，专门用于治疗。 适应症结合生理指标(心率、皮肤电反应)、TMS和MRI神经- 反馈。然而，这些研究目标的实现依赖于收集标准化的、 可复制的数据，这依赖于具有内置验证功能和深度的高质量设备 技术专长。为此，这里概述的最先进设备在核心环境中的可用性 使基于脑电的生物标记物和治疗应用的整合成为可能，所有关注的研究人员 关于改善心理健康结果的。

ABSTRACT This grant application requests funding for the purchase of a high-density electroencephalography (EEG) system to reside in the Human Neurophysiology Core at Boston Children's Hospital. The EEG system offers state-of- the-art technology that will allow investigators flexibility in experimental design to incorporate event related potentials, magnetic resonance imaging (MRI) co-acquisition, transcranial magnetic stimulation (TMS) application and physiology co-registering into high density EEG collection. The equipment selected has been optimized for EEG biomarker collection in pediatric populations, including infants, young children, children with neurodevelopmental delays and neuropsychiatric symptomatology. Importantly, the equipment will be located within a Core facility staffed with experts in the design, collection and analysis of EEG data enabling users to obtain impactful results related to a broad array of NIMH funded research aims. EEG is being incorporated into an increasing number of research studies due to the capacity of this technique to yield high quality data reflecting neural function and connectivity from sensitive populations. Biomarkers of disease state, prognostics, stratification and treatment response have been identified in a number of neuropsychiatric disorders including autism spectrum disorder, ADHD, psychotic disorders and depression/anxiety. Furthermore, considerable EEG research is being undertaken specifically for therapeutic indications in combination with physiological measures (heart rate, galvanic skin response), TMS and MRI neuro- feedback. The realization of these research goals, however, is dependent on the collection of standardized, reproducible data, which is dependent on high quality equipment with built-in validation capabilities and deep technical expertise. To this end, availability of the state-of-the art equipment outlined here within a core setting makes incorporation of EEG based biomarkers and therapeutic applications possible for all investigators focused on improving mental health outcomes.