Biospecimen Core

生物显微镜-病理学核心：项目总结 美国的大多数生物标本都是从北欧血统的个体身上收集的，这限制了 结论的概括性。迫切需要增加高质量生物检疫剂的可用性。 少数族裔和少数族裔的转化型肺癌差异研究。的一个重要目标 肺癌差异翻译研究中心(TRACE)生物医学/病理学核心(BPC)是为了 协调与收集、处理、储存和分发带注释的人类生物标本有关的工作 对于所有参与的地点和项目，包括由 发展研究计划(DRP)。Tracer BPC团队将专家聚集在一起，共享 致力于消除差异，这一联盟将通过机构协议和标准正式形成 操作程序(SOP)。Tracer BPC将为翻译差异研究人员提供访问 扩展了一系列生物样品、分析技术和带有临床数据和社会数据的注释 健康数据的决定因素。BPC导联和联合导联是肺癌病理学领域的老牌领先者， 生物仓库、癌症信息学、地理空间分析、行为健康和癌症生物学家提供 分子分析技术--所有这些技术都致力于差异和翻译研究。示踪剂BPC 标本将共同存放在弗吉尼亚联邦大学的梅西癌症中心)， 南卡罗来纳州(MUSC)医科大学霍林斯癌症中心和希望之城 癌症中心。VCU将成为中心IRB，并将建立通用的SOP、数据元素和平台。 VCU将汇编和整合数据，数据将上传到喷气推进实验室(JPL；NASA)服务器。 喷气推进实验室储存和整合早期探测研究网络(EDRN)数据。房屋跟踪器数据 喷气推进实验室将促进未来的示踪剂-EDRN合作。AIM 1将提供一个示踪剂 协作调查人员可以通过统一的SOP获取人体组织、体液和血液样本 这个P20的研究项目具有很高的严密性和重复性。目标2将收集和注释标本 包括人口统计数据、临床数据、组织病理学结果、分子注释和社会决定因素 健康数据。与跟踪生物统计和生物信息学核心合作，跟踪调查人员将拥有 访问完全集成的集中式信息源。AIM 3将扩大示踪剂调查人员进入 通过与国家癌症研究所的合作，实现尖端技术和人工智能分析 研究所的早期检测研究网络(EDRN)。

BIOSPECIMEN-PATHOLOGY CORE: PROJECT SUMMARY Most biospecimens in the US are collected from individuals of Northern European ancestry, limiting the generalizability of findings. There is an urgent need to increase the availability of high-quality biospecimens from ethnic and racial minorities for translational lung cancer disparities research. A significant goal of the Translational Research Center in Lung Cancer Disparities (TRACER) Biospecimen/Pathology Core (BPC) is to coordinate efforts related to collection, processing, storage, and distribution of annotated human biospecimens for all participating sites and projects, including the a future pilot research projects supported by the Developmental Research Program (DRP). The TRACER BPC team brings together experts with a shared dedication to eradicating disparities, and this union will be formalized by institutional agreements and standard operating procedures (SOPs). The TRACER BPC will provide translational disparities researchers access to an expanded array of biospecimens, analytical techniques, and annotations with clinical data as well as social determinants of health data. The BPC Lead and Co-Leads are established leaders in lung cancer pathology, biorepositories, cancer informatics, geospatial analysis, behavioral health and cancer biologists offering molecular analysis techniques – all committed to disparities and translational research. TRACER BPC specimens will be jointly housed at the Massey Cancer Center at Virginia Commonwealth University VCU), the Hollings Cancer Center at the Medical University South Carolina (MUSC) and the City of Hope Comprehensive Cancer Center. VCU will be the central IRB, andcommon SOPs, data elements, and platforms will be established. VCU will compile and integrate data, and data will be uploaded to the Jet Propulsion Lab (JPL; NASA) server. JPL houses and integrates the Early Detection Research Network (EDRN) data. Housing TRACER data with JPL will facilitate future TRACER-EDRN collaborations. Aim 1 will provide a portal through which TRACER collaborative investigators can acquire through uniform SOP’s the human tissues, fluids, and blood samples for research projects of this P20 with high rigor and reproducibility. Aim 2 will collect and annotate specimens including demographic data, clinical data, histopathologic results, molecular annotation and social determinants of health data. Working with the TRACER Biostatistics and Bioinformatics Core, TRACER investigators will have access to a fully integrated centralized information source. Aim 3 will expand TRACER investigators’ access to cutting-edge technology and artificial intelligence analytics through a partnership with the National Cancer Institute’s Early Detection Research Network (EDRN).