Project 2: Peripheral Electrophysiology

项目负责人/主要研究者（最后一位、第一位、中间一位）：J. J. J.布鲁斯。 摘要-项目2 人工耳蜗植入体（CI）技术正在不断发展。如今，CI专门设计用于 并且许多接受者在其植入的耳中享受声学听力的保留 手术后。语音处理器也可以通过两种方式来协调声音的传递。 声刺激和电刺激模式。我们将这组CI用户称为A+E听众，他们是 本提案的重点。 将讨论两个具体目标。目标1首先观察到， 一组CI用户是好的，但注意到个人的结果仍然有相当大的差异。的 本提案中所列的研究旨在查明结果差异的原因。我们假设 外周听觉系统的状态在确定A+E的结果中可能特别重要 听众一系列的电生理措施提出，我们将使用的特点的反应 听觉周边的听觉和电刺激。我们提出的方法是新颖的。 在我们以前的工作中，我们使用电刺激来评估听觉外周的状态。 电刺激绕过耳蜗毛细胞。本提案中包括的研究将使用声学 刺激和位于耳蜗内的电极，以记录来自两个耳蜗毛细胞的神经活动 和听觉神经。这些对声刺激的反应将补充测量如何 听觉神经对电刺激的反应，其结果将是一个更全面的表征 外围听觉系统的完整性和功能。我们还首次提议， 将基因检测结果输入模型，用于预测结果。一系列的实验将集中在 频谱和时间线索是如何在听觉外围处理的，这些结果可以作为 多元回归分析中的独立变量，将用于确定独立 噪声环境下多种因素对言语感知的影响。 我们的第二个目标将集中在使用我们的扩展电池的电生理记录方法，以帮助我们 我理解为什么A+E听众的一部分经历了他们的听觉损失，往往几个月 手术后。我们将密切跟踪每个研究参与者，并将行为阈值的变化与 耳蜗内电极阻抗、电流模式和电生理测量的变化 周围听觉系统对声刺激和电刺激的反应。我们的假设是 随着时间的推移，这些指标的变化将为关于为什么这种延迟性听觉丧失的理论提供信息。 并反过来提出潜在的治疗方案。 OMB编号0925-0001/0002（2016年3月修订版，批准至2018年10月31日）

Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. ABSTRACT – PROJECT 2 Cochlear implant (CI) technology is continually evolving. Today, CIs have been designed specifically to preserve cochlear structures and many recipients enjoy preservation of acoustic hearing in their implanted ear following surgery. Speech processors are also available that allow coordinated delivery of sound via both acoustic and electric stimulation modes. We refer to this group of CI users as A+E listeners and they are the focus of this proposal. Two specific aims will be addressed. Aim 1 starts with the observation that average performance levels for this group of CI users are good, but notes that there is still considerable variance in outcome for individuals. The studies included in this proposal are designed to identify reasons for that variance in outcome. We hypothesize that the status of the peripheral auditory system may be particularly important in determining outcome for A+E listeners. A series of electrophysiologic measures are proposed that we will use to characterize the response of the auditory periphery to both acoustic and electrical stimulation. The methods we propose to use are novel. In our previous work we have used electrical stimulation to assess the status of the auditory periphery. Electrical stimulation bypasses the cochlear hair cells. The studies included in this proposal will use acoustic stimulation and an electrode located inside the cochlea to record neural activity from both cochlear hair cells and from the auditory nerve. These responses to acoustic stimulation will complement measures of how the auditory nerve responds to electrical stimulation and the result will be a more comprehensive characterization of the integrity and function of the peripheral auditory system. We also propose, for the first time, to incorporate results of genetic testing into the model will use for predicting outcome. One series of experiments will focus on how spectral and temporal cues are processed at the auditory periphery and those results serve as independent variables in a multivariate regression analysis that will be used to determine the independent contributions of multiple factors to speech perception in noise. Our second aim will focus on using our expanded battery of electrophysiologic recording methods to help us understand the reason that a subset of A+E listeners experience loss of their acoustic hearing often months after surgery. We will follow each study participant closely and correlate changes in behavioral thresholds with changes in electrode impedance, current flow patterns within the cochlea and electrophysiologic measures of the response of the peripheral auditory system to both acoustic and electric stimulation. Our hypothesis is that changes over time in these metrics will inform theories regarding why this delayed loss of acoustic hearing takes place and, in turn, suggest potential treatment options. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page