Lens epithelial cell heterogeneity during development

晶状体前单层上皮细胞的增殖、分化和动态平衡 镜头的生长、大小、形状和透明度，这些都是调焦和 将光图像传输到视网膜上。这项提议的目的是检验一种新的假设 晶状体上皮细胞的内在异质性调节晶状体生长和动态平衡， 晶状体单层上皮的独特细胞团被精确地组织起来，以调节 眼周围组织的外部信号和环境刺激对晶状体的调节 生长、大小、形状和透明度，以及特定细胞团破坏(S)会损害 调节晶状体生长和动态平衡导致各种晶状体和/或眼部病理结果 包括白内障、小眼炎和巨噬眼炎。

The proliferation, differentiation and homeostasis of lens anterior monolayer epithelium determine the lens growth, size, shape and transparency, which are absolutely required for focusing and transmitting a light image onto the retina. The goal of this proposal is to test a novel hypothesis that the intrinsic heterogeneity of lens epithelial cells regulates lens growth and homeostasis, and distinctive cell clusters of lens monolayer epithelium are precisely organized for mediating external signals of surrounding ocular tissues and environmental stimuli to regulate the lens growth, size, shape and transparency, and that disruptions of specific cell cluster(s) impair the regulation of lens growth and homeostasis to lead to various lens and/or eye pathological outcomes including cataracts, microphthalmia, and macrophthalmia.