Cerebellar parvocellular modules

项目摘要 小脑与许多神经学和神经精神病学有关。 从运动障碍，如共济失调，震颤，平衡失调到自闭症， 精神分裂症和冲动。我们不知道为什么一些小脑功能障碍的患者 体验主要是运动症状，而其他人则患有情绪失调和心理健康 挑战。在这项提议中，我们研究了负责不同的 小脑运动和非运动功能障碍。结合严格的解剖学方法， 包括专门的病毒电路跟踪载体，提供有关全脑神经元的新信息 连接，这项研究将检验特殊类型的小脑输出神经元的假设 对与小脑相关的各种疾病负有不同的责任。 这些实验目标的实现将产生关于大脑的重要新信息-- 不同类型的小脑输出神经元建立的广泛联系将使 开发新的诊断和治疗策略，适用于各种运动性和运动性脑血管疾病患者 神经精神障碍。

Project Summary The cerebellum has been implicated in a remarkable number of neurological and neuropsychiatric disorders that range from motoric deficits such as ataxia, tremor, and disequilibrium to autism, schizophrenia, and impulsivity. We do not know why some patients with dysfunction in the cerebellum experience primarily motoric symptoms while others suffer from dysregulated mood and mental health challenges. In this proposal, we examine the specific neural circuits that are responsible for diverse cerebellar motoric and non-motoric dysfunctions. Using a combination of rigorous anatomical methods, including specialized viral circuit tracing vectors that provide new information about brainwide neuronal connections, this research will test the hypothesis that specialized types of cerebellar output neurons are differentially responsible for the diverse disorders associated with the cerebellum. Accomplishments of these experimental goals will generate important new information about the brain- wide connections made by different types of cerebellar output neurons which will enable the development of new diagnostic and therapeutic strategies for patients with a wide range of motoric and neuropsychiatric disorders.