A Complete Metal Artifact Reduced MRI Exam for Neuroimaging

项目摘要 用于减少矫形植入物的磁共振成像（MRI）中的金属伪影的技术已经 在过去的十年里取得了巨大的进步。将这些技术扩展到其他应用， 包括脑成像技术仍然不发达。因此，MRI对比对于神经成像至关重要-例如 如T2-FLAIR加权、加权、扩散加权和血管造影-尚未积极探索。在 与此同时，颅内植入物或可安全成像的装置已经激增， 神经影像学检查中的金属伪影使其无法诊断。这项工作的目标是 开发和优化金属伪影减少采集，以部署功能齐全的神经成像 临床检查 拟议工作的第一个目标是开发MRI对比的采集和重建， 神经影像学检查需要，但目前还没有。目前可用的对比包括T1加权， T2加权，以及在初步格式中，扩散加权。对于神经成像应用，类似金属 伪影减少原则将被用于产生T2-FLAIR、加权和血管造影采集。小说 最近已经论证了开发新的拟议收购所需的原则 在针对骨科植入物的项目背景下。在这份提案中，这些新的发展将是 翻译为解决神经成像特定应用。 拟议研究的第二个目的是评估现有的和新的金属伪影减少收购， 神经影像学检查中的诊断性能。几个定量指标之间的比较， 将进行常规和拟定的神经MRI检查。比较的指标将包括工件 音量、信噪比和噪声对比度。最后，新提出的金属的诊断性能 伪影缓解神经MRI检查将在随机阅片人研究中进行评价。 完成拟议的工作可能会产生一个完整的金属工件所需的基础技术 减少神经MRI检查。在目前的研究中，将开发和测试这项技术。 到适合未来临床试验的程度，以评估其作为主要诊断工具的性能。 最终，这项工作将导致新的诊断神经MRI检查的患者， 当前的技术产生非诊断MRI数据。

Project Summary Techniques for reducing metal artifacts in magnetic resonance imaging (MRI) of orthopaedic implants have seen tremendous improvement in the last decade. Extensions of these technologies to other applications, including brain imaging, remain under-developed. As a result, MRI contrasts essential for neuroimaging – such as T2-FLAIR weighting, weighting, diffusion weighting, and angiography – have not been actively explored. At the same time, intra-cranial implants or devices which are safe to image have proliferated, and a growing number of neuroimaging exams include metal artifacts which render them non-diagnostic. It is the goal of this work to develop and optimize metal artifact reduced acquisitions for the deployment of a fully-functioning neuroimaging clinical exam. The first aim of the proposed work seeks to develop acquisitions and reconstructions for MRI contrasts which are needed for neuroimaging exams, and are not yet available. Currently available contrasts include T1-weighting, T2-weighting, and in a preliminary format, diffusion-weighting. For application to neuroimaging, similar metal artifact reduction principles will be leveraged to yield T2-FLAIR, -weighted, and angiographic acquisitions. Novel principles necessary for the development of the new proposed acquisitions have recently been demonstrated within the context of projects targeting orthpaedic implants. In this proposal, these new developments will be translated to address neuroimaging-specific applications. The second aim of the proposed study seeks to evaluate existing and new metal artifact reduction acquisi- tions for diagnostic performance in neuroimaging exams. Several quantitative metric comparisons between the conventional and proposed neurological MRI exams will be performed. Compared metrics will include artifact volume, signal to noise, and contrast to noise. Finally, the diagnostic performance of the newly proposed metal artifact mitigated neurological MRI exam will be evaluated in a randomized reader study. Completion of the proposed work could yield foundational technology necessary for a complete metal artifact reduced neurological MRI examination. Within the current study, this technology will be developed and tested to the point of appropriateness for future clinical trials to assess its performance as a primary diagnostic tool. Ultimately, this work will lead to the availability of new diagnostic neurological MRI exams in patients where current technologies yield non-diagnostic MRI data.