Humanized Mouse Core

摘要-人性化的鼠标核心(核心A) HuNSG小鼠模型很好地概括了人类生物学的一些方面，这些方面在其他 系统。这种人性化的小鼠模型也提供了唯一能够支持人巨细胞病毒的小动物模型 感染、潜伏期和重新激活。此PPG需要我们高度标准化的huNSG模型，以便 有效地表征独特的条件并定量区分病毒的生长和传播 不同的病毒突变体和治疗方法。核心A将提供以下所需的基础设施和知识 完成了涉及huNSG小鼠的拟议研究项目，并对所有 允许直接比较的项目。通过直接与项目负责人合作，Core A将帮助 设计和实施拟议的实验。

SUMMARY - HUMANIZED MOUSE CORE (CORE A) The huNSG mouse model nicely recapitulates aspects of human biology that are not supported in other systems. This humanized mouse model also offers the only small animal model capable of supporting HCMV infection, latency, and reactivation. This PPG requires our highly standardized huNSG model in order to effectively characterize unique conditions and quantitatively differentiate viral growth and dissemination of different viral mutants and treatments. Core A will provide the infrastructure and knowledge required for completion of the proposed research projects involving huNSG mice and standardize analysis between all projects to allow for direct comparisons. By working directly with the Project leaders, Core A will aid in designing and execution of the proposed experiments.