CANCER CENTER SUPPORT GRANT

总体--摘要 卡马诺斯癌症研究所(KCI)成立于1943年，是一个非营利性的、仅针对癌症的研究和患者 与密歇根州韦恩州立大学(WSU)合作的CARE组织。由NCI指定 作为一个综合性的癌症中心，于1978年实现。KCI运营其全资拥有的、独立的、 底特律和郊区的法明顿山庄的癌症医院和门诊诊所(KCC)。作为一名 迈凯轮健康护理(MHC)是一家非营利性医疗保健公司，KCI也负责 在MHC拥有和运营的所有设施中进行癌症研究、护理质量和癌症护理操作。我们的 集水区覆盖了密歇根州83个县中的46个县，人口670万。这个集水区 该地区是我们95%的患者的家园，KCI在集水区看到了三分之一的新癌症患者。 我们集水区的东南部地区包括底特律大都会，被定义为三县地区 (韦恩，奥克兰，马科姆)和386万居民的家园。底特律是世界上最大的城市 州(672,000居民)。底特律是一个资源短缺的地区，家庭收入中位数为27,838美元 37.9%的居民生活在贫困线以下，而密歇根州的这一比例为16.7%。大多数人 根据HRSA的定义，底特律市的人口普查区域是医疗服务不足的地区。约79%的 底特律居民认为非裔美国人是一个不成比例的群体，他们携带着KCI集水区的 癌症负担。 2018年，KCI医生看到了大约12,000名新的癌症患者(包括大约8,000名分析 案例)，其中约15%代表少数群体。每年的癌症新发个案数目 这46个县约为3.9万个，自2014年以来没有明显变化。在19财年，我们的少数族裔 介入治疗方案的有效率为24.2%。我们有悠久的科学和病人护理 对密歇根州东南部非洲裔美国人的承诺，如广泛的一系列 研究的重点是分子、治疗和社会差异。此应用程序分析了以下优势和 我们四个科学项目的成功，肿瘤生物学和微环境(TBM，01)，分子 影像学(MI，02)、分子治疗学(MT，03)、人群研究和差异研究 (PSDR，04)。这些项目的研究工作得到了九个共享资源(核)的支持， 包括一个正在开发的核心。截至2019年12月，KCI的135个科学成员已确保 年度直接项目资金63162159美元(比2015年增加12.3%)，其中21864688美元为同业项目 审查了资金，11,743,830美元来自NCI。

OVERALL - ABSTRACT The Karmanos Cancer Institute (KCI), founded in 1943, is a not-for-profit, cancer-only research and patient care organization in partnership with Wayne State University (WSU) in Michigan. The designation by the NCI as a Comprehensive Cancer Center was achieved in 1978. KCI operates its wholly-owned, free-standing, cancer hospital and ambulatory clinics (KCC) in Detroit and in Farmington Hills, a suburban location. As a member of McLaren Health Care (MHC), a not-for profit health care corporation, KCI is also responsible for cancer research, quality of care, and cancer care operations in all facilities owned and operated by MHC. Our catchment area covers 46 of Michigan’s 83 counties with a population of 6.7 million people. This catchment area is home to 95% of our patients, and KCI sees one-third of all new cancer patients in the catchment area. The Southeast region of our catchment area includes the metropolitan Detroit, defined as a tri-county area (Wayne, Oakland, Macomb) and home to 3.86 million residents. The city of Detroit is the largest city in the state (672,000 residents). Detroit is a resource-challenged area, with a median household income of $27,838 and 37.9% of residents living below poverty level, compared to 16.7% in the state of Michigan. The majority of census tracts in the city of Detroit are medically underserved areas based on HRSA definitions. About 79% of Detroit residents identify as African American, a group that disproportionately carries KCI catchment area’s cancer burden. In 2018, KCI physicians saw approximately 12,000 new cancer patients (including approximately 8,000 analytic cases), with approximately 15% representing minority groups. The annual number of new cancer cases in these 46 counties is approximately 39,000 and has not changed significantly since 2014. In FY19, our minority accrual to interventional treatment protocols was 24.2%. We have a long standing scientific and patient care commitment to the African American population of southeastern Michigan, as exemplified in the broad array of studies focused on molecular, therapeutic, and social disparities. This application profiles the strengths and successes of our four scientific Programs, Tumor Biology and Microenvironment (TBM, 01), Molecular Imaging (MI, 02), Molecular Therapeutics (MT, 03), and Population Studies and Disparities Research (PSDR, 04). The research efforts of these Programs is supported by nine Shared Resources (Cores), including one developing Core. As of December 2019, KCI’s 135 scientific members have secured total annual direct project funding of $ 63,162,159 (an increase of 12.3% from 2015) of which $21,864,688 is peer reviewed funding and $11,743,830 is from the NCI.