Component A: Wisconsin Study to Explore Early Development of Autism (SEED)

摘要 该提案旨在为威斯康星州建立一个招募、数据收集和合作研究网站， 自闭症谱系障碍（ASD）的多点研究探索早期发展（SEED）中心 疾病控制和预防（CDC）。SEED的总体目标是： 变异性，并确定相对同质的ASD亚组;并通过以下方法研究ASD的风险因素： 比较早期暴露和发展的良好特征的ASD病例和对照选择， 代表了不同的人口亚群。该项目的具体目标是：（1）实施第三次种子发展方案 该协议在威斯康星州南部和中部的20个县的集水区（2014年出生4,015人）， 包括威斯康星州自闭症和发育障碍监测（ADDM）网络流域 作为CDC ADDM网络的一部分，ASD和其他发育障碍的监测领域 自2002年监测年以来一直在进行;（2）加强招募，实现招募和数据 收集375名儿童及其父母的目标，如SEED 3方案所规定的;（3）提交数据， 根据SEED 3方案收集的生物样本， 残疾研究流行病学（CADDRE）数据协调中心和SEED中心实验室， 生物样品库;以及（4）与CADDRED其他成员合作， 参与相关CADDRE工作组、数据分析和手稿编写，至少包括 由威斯康星州种子研究小组领导的五份手稿。这项研究将产生新的知识 ASD的风险因素和潜在预防，ASD是儿童残疾的主要类别， 影响整个生命周期。

Abstract This proposal is to establish a recruitment, data collection and collaborative research site in Wisconsin for the multi-site Study to Explore Early Development (SEED) of autism spectrum disorder (ASD) of the Center for Disease Control and Prevention (CDC). The overall goals of the SEED are to: characterize phenotypic variability and identify relatively homogeneous subgroups of ASD; and investigate risk factors for ASD by comparing the early exposures and development of well-characterized ASD cases and controls selected to represent diverse population subgroups. The specific aims of this project are to: (1) implement the SEED 3 protocol in a 20-county catchment area (4,015 births in 2014) in south and central Wisconsin that encompasses the Wisconsin Autism and Developmental Disabilities Monitoring (ADDM) Network catchment area where surveillance of ASD and other developmental disabilities as part of CDC's ADDM Network has been underway since surveillance year 2002; (2) to enhance recruitment and achieve enrollment and data collection targets for 375 children and their pares, as specified in the SEED 3 protocol; (3) submit data and biospecimens collected according to the SEED 3 protocol to the Centers for Autism and Developmental Disability Research Epidemiology (CADDRE) Data Coordinating Center and SEED Central Laboratory and Biosample Repository, respectively; and (4) collaborate with other CADDRED members and actively participate in relevant CADDRE workgroups, data analysis and preparation of manuscripts, including at least five manuscripts to be led by the Wisconsin SEED research team. This research will generate new knowledge of the risk factors for and potential prevention of ASD, a leading category of disability among children, with effects across the lifespan.