The Early Detection Research Network: Data Management and Coordinating Center

 描述(由申请人提供)：S早期检测研究网络成功的关键在于多学科科学家之间的良好沟通；对有希望的生物标志物进行有效的评估和优先排序；以及严格的验证研究以证明其临床实用。拟议更新数据管理和协调中心(DMCC)的总体目标是：(1)协调EDRN，以加强EDRN研究人员之间以及与普通科学界的沟通和合作；(2)协调EDRN验证研究；(3)向更广泛的科学界和公众传播癌症生物标记信息；(4)管理EDRN核心基金。在EDRN指导委员会的指导下，DMCC将1)开展网络协调，促进科学研究人员之间的合作，为EDRN会议和讲习班提供支持，开发和维护EDRN安全网站和列表服务器，制作和维护所有EDRN文件，并维护提交EDRN的申请的在线审查系统；2)通过开发和维护验证研究数据管理系统，支持EDRN验证研究；与EDRN研究人员就研究设计、方案制定、数据表格和研究手册进行合作；协调和监测研究；跟踪标本；以及进行质量保证/质量控制和研究评估；3)与NCI和JPL合作，为EDRN安全网站提供信息资源，用于数据安全、数据仓储和数据共享，并提供公共网站供传播；以及4)与EDRN SC、NCI项目协调员和FHCRC OSR密切合作，在EDRN SC批准后及时激活核心资金，并确保遵守所有法规对分标管理的要求。

 DESCRIPTION (provided by applicant): The key for the Early Detection Research Network (EDRN)'s success lies in good communication among scientists in multiple disciplines; efficient evaluation and prioritization of promising biomarkers; and rigorous validation studies to demonstrate their clinical utility. The overall aims of the proposed renewal of the Data Management and Coordinating Center (DMCC) are to (i) provide coordination of EDRN in order to enhance communication and collaboration among EDRN investigators and with general scientific communities; (ii) coordinate EDRN validation studies; (iii) disseminate cancer biomarker information to broader scientific communities and the public; and (iv) mange the EDRN Core funds. Under the direction of the EDRN Steering Committee, the DMCC will 1) perform network coordination and promote collaborations among scientific investigators by providing support for EDRN meetings and workshops, developing and maintaining EDRN secure websites and listservs, producing and maintaining all EDRN documents, and maintaining the online review system for applications submitted to the EDRN; 2) support EDRN validation studies by developing and maintaining validation study data management systems; working with EDRN investigator on study design, protocol development, data forms, and study manuals; coordinating and monitoring studies; tracking specimens; and performing QA/QC and study evaluation; 3) work with the NCI and JPL to provide informatics resources for the EDRN Secure Web site for data security, data warehousing, and data sharing, and a Public Web site for dissemination; and 4) work closely with the EDRN SC and the NCI Project Coordinator and FHCRC OSR to timely activate the core funds after the EDRN SC approval and ensure the compliance of all regulatory requirements for sub-award management.