Pilot Project Program

项目总结 试点项目方案(PPP)在实现辛辛那提大学的使命方面发挥了关键作用 环境遗传学中心(CEG)，专注于基因-环境相互作用(GxE) 研究。公私合作伙伴关系的总体目标是为新的研究项目提供种子支持 环境健康科学(EHS)，这将为CEG的GxE研究重点提供新的线索。目标是 是允许调查人员，无论是老牌的还是新手，获得重要的初步数据，这些数据可以 成为新的NIH/NIEHS拨款提案(S)及相关出版物的基础。要做到这一点， 将使用以下六种不同的奖励机制：新的(早期)调查者奖、创新者奖、 EHS新手调查员奖、亲和力小组奖、翻译和社区参与奖，以及 时间敏感响应奖。CEG-PPP依赖于其试点项目的内部和外部审查 并建立了一个中心间审查员联盟，涉及四个由NIEHS资助的P30 EHS 中锋。审查过程与美国国立卫生研究院遵循的形式密切一致。审查标准和 评分标准(1-9)类似于NIH审查流程，允许我们向申请者提供有意义的反馈，如 以及帮助该中心在NIH类型的审查过程中培训初级教职员工。PPP具有内置的 通过定期进度报告跟踪试点奖励的进展和结果的机制 (包括专业演讲、出版物、校外赠款)和年度试点项目专题讨论会 面向CEG成员和大学校园内更广泛的受众。总体而言，PPP 计划在许多方面都是一个重要的工具，比如帮助初级侦探在他们的职业追求中， 招募新的研究人员进入EHS研究领域，激发新的研究思路，填补空白 在CEG研究议程中，促进设施核心的使用，建立跨学科的研究团队 促进翻译和社区参与活动。从本质上讲，PPP服务于整合所有其他 通过其奖励机制为中心的组成部分提供支持，并帮助各个CEG核心实现其 目标。中心内部咨询委员会将继续审查CEG-PPP的业绩 和外部咨询委员会，并以两个关键标准来判断：根据后续的投资回报 获得资助的试点项目产生的外部资金和出版物。CEP-PPP努力实现 保持其在引导试点资金用于EHS最有前途的项目方面的卓越表现，并支持 新的调查人员(包括早期和新手)，以促进获得新的和 GxE研究的创新方向。

PROJECT SUMMARY The Pilot Project Program (PPP) has played a key role in pursuing the mission of the University of Cincinnati's Center for Environmental Genetics (CEG) with a thematic focus on gene-environment interaction (GxE) research. The overall objective of the PPP is to provide seed support for new research initiatives in environmental health sciences (EHS) that will shed new light on the GxE research focus of the CEG. The goal is to allow investigators, either established or new to the field, to obtain significant preliminary data that can become the basis of new NIH/NIEHS grant proposal(s) and associated publications. To accomplish this, the following six different award mechanisms will be used: New (early stage) Investigator Award, Innovator Award, New-to-EHS Investigator Award, Affinity Group Award, Translation and Community Engagement Award, and Time-Sensitive Response Award. The CEG-PPP relies on both internal and external reviews of its pilot applications and has developed an Inter-Center Reviewer Consortium involving four NIEHS-funded P30 EHS Centers. The review process is aligned closely with the format followed at the NIH. Review criteria and the score scale (1-9) similar to NIH review process allow us to provide a meaningful feedback to the applicants as well as help the Center train its junior faculty in the NIH-type review process. The PPP has a built-in mechanism to track the progress and outcome of the pilot awards through a regular progress reporting (including professional presentations, publications, extramural grants) and an annual Pilot Project Symposium directed at a broader audience across the CEG membership and the university campus. Overall, the PPP program is an important vehicle in multiple ways such as helping junior investigators in their career pursuits, recruiting new investigators into the field of EHS research, stimulating novel research ideas and filling the gaps in CEG research agenda, promoting facility cores usage, building trans-disciplinary research teams and facilitating translation and community engagement activities. In essence, the PPP serves to integrate all other components of the Center through its award mechanisms, and helps the individual CEG cores realize their goals. The performance of the CEG-PPP will continue to be reviewed by the Center's Internal Advisory Board and External Advisory Board and judged by two key criteria: Return on Investment in terms of subsequent extramural funding and Publications emanating from the funded pilot projects. The CEP-PPP strives to maintain its excellence in channelizing the pilot funds to the most promising projects in EHS and supporting new investigators (both Early Stage and New-to-EHS) to facilitate obtaining extramural funding on new and innovative directions in GxE research.