Cancer Epidemiology and Population Science

项目摘要/摘要 癌症流行病学和人口科学(CEPS)研究计划主要关注#年的癌症。 爱荷华州霍尔顿综合癌症中心(HCCC)集水区，同时认识到其影响 远远超出了该州的范围。CEPS的主要目标是进行基于人口的研究， 提高我们对癌症病因、发病率和死亡率的了解，以便探索干预措施 降低癌症发病率和死亡率，提高癌症幸存者的生活质量。这就完成了 通过围绕1)癌症病因学，2)原发和继发性癌症的三个相关研究目标 预防和3)癌症保健服务和结果。最近有影响力的CEPS出版物 解决淋巴瘤、慢性淋巴细胞性白血病、对侧乳腺癌、胰腺癌和乳腺癌 生存、压力和临终问题，以及美国预防服务工作队 关于癌症预防和筛查的建议。CEP成员包括28名正式成员和9名助理成员 成员跨越五所学院的17个系。同行评议研究的年度直接资助总额 上一个预算年度为430万美元，其中150万美元来自NCI。CEP成员的工作效率很高， 自2016年以来撰写或共同撰写了372份与癌症相关的同行评议出版物，并高度 协作性，其中24%(n=91)在方案内，18%(n=70)在方案间，63%(n=235) 跨机构出版物。其中52篇发表在影响力较大的期刊上(影响因子 &gt；10)。成功的计划内/计划间和多机构合作正在产生重要的癌症-- 农药和多氯联苯暴露知识的相关进展；淋巴瘤、肉瘤、 乳腺癌、卵巢癌和结直肠癌；HPV相关癌症和疫苗；多病科学； 癌症筛查和戒烟。

PROJECT SUMMARY/ABSTRACT The Cancer Epidemiology and Population Science (CEPS) research program focuses primarily on cancer in Iowa, the Holden Comprehensive Cancer Center (HCCC) catchment area, while recognizing that its impact extends well beyond the state. The primary goal of the CEPS is to conduct population-based research that improves our understanding of cancer etiology, morbidity, and mortality in order to explore interventions for reducing cancer incidence and mortality and improving quality of life for cancer survivors. This is accomplished through three related research aims centered on 1) cancer etiology, 2) primary and secondary cancer prevention and 3) cancer health care services and outcomes. Recent influential CEPS publications have addressed lymphoma, chronic lymphocytic leukemia, contralateral breast cancer, pancreatic and breast cancer survival, stress, and end-of-life issues, as well as United States Preventive Services Task Force recommendations for cancer prevention and screening. CEPS membership includes 28 full and nine associate members spanning 17 departments across five colleges. Annual total direct funding for peer-reviewed research in the last budget year was $4.3 million with $1.5 million from the NCI. CEPS members are highly productive, having authored or co-authored 372 cancer-related peer-reviewed publications since 2016, and highly collaborative, with 24% (n=91) intraprogrammatic, 18% (n=70) interprogrammatic, and 63% (n=235) interinstitutional publications. Fifty-two of these publications appeared in high impact journals (Impact Factor >10). Successful intra/interprogrammatic and multi-institutional collaborations are generating important cancer- related advances in knowledge about pesticide and polychlorinated biphenyl exposures; lymphoma, sarcoma, and cancers of the breast, ovary, and colorectum; HPV-related cancer and vaccination; multimorbidity science; cancer screening; and tobacco cessation.