Consortium-Wide Coordinating Core

摘要 我们建议满足NIAID中心对辐射医学对策的需求 用于1)管理基础设施的财团(CMCRC)，以组织互动和促进协作 在CMCRC调查人员中，2)监督使用资金刺激试点研究的项目，3)及时分享 在CMCRC调查人员和 4)生物统计和生物信息学支助，以响应AI-10-012，并配备工作人员 他们带来了在NHLBI前体细胞生物学联盟类似领域工作的多年经验 (PCBC)行政协调中心(ACC)和祖细胞翻译联盟(PCTC) 行政协调中心(ACC)。拟议的调查人员和工作人员在以下方面具有丰富的经验 协调中心，组织会议，合作协议下的合作研究， 财团基础设施、网站、通信、监测和文件。 我们将调整和改进我们的基础设施(硬件、软件、网站和链接、办公室、办公室 设备和工作人员)，以便PCBC ACC和PCTC ACC延伸到CMCRC，从而导致 CMCRC联合体范围协调中心(CCC)在第一天立即开始运行。我们会 继续将现有基础设施的功能扩展到更多、创新地使用社交媒体，以 接触到CMCRC社区的所有角落，并延伸到更广泛的研究社区。中华儿科研究中心 财团范围的协调中心将遵循它已经建立并正在用于其他NIH的程序- 支持协调中心执行必要的行政任务，以召开财团会议和 电话会议，准备议程和会议纪要，管理培训和教育资金，并支持网络 用于通信、数据传输、信息和方法描述(例如，协议)的站点 要求共享试剂、生物材料和(动物)模型。 我们的建议是高效和创新的，因为我们的专业知识和经验 调查人员，他们彼此备份的不可中断性质，以及 我们将从PCBC和PCTC扩展和更新系统到CMCRC。将资源输送到 翻译研究，支持翻译研究所必需的基础研究，以及我们的 通过社交媒体进行的基础设施将是巨大的。

Abstract We propose to meet the need of the NIAID Centers for Medical Countermeasures Against Radiation Consortium (CMCRC) for 1) administrative infrastructure to organize interactions and facilitate collaboration among CMCRC investigators, 2) oversight of programs using funds to stimulate Pilot Studies, 3) timely sharing of CMCRC-generated data, biomarkers, (animal) models and reagents among CMCRC investigators and with the research community, and, 4) biostatistics and bioinformatics support, in response to AI-10-012, with staff who bring years of experience working along similar lines in the NHLBI Progenitor Cell Biology Consortium (PCBC) Administrative Coordinating Center (ACC) and the Progenitor Cell Translational Consortium (PCTC) Administrative Coordinating Center (ACC). The proposed investigators and staff have extensive experience in coordinating centers, organization of meetings, collaborative research under cooperative agreements, consortium infrastructure, web site, communications, monitoring and documentation. We will adapt and advance our infrastructure (hardware, software, web sites and links, offices, office equipment and staff) in place for the PCBC ACC and PCTC ACC to extend to the CMCRC resulting in an immediate, running start for the CMCRC Consortium-wide Coordinating Center (CCC) on day one. We will proceed to expand the functions of the extant infrastructure to additional, innovative use of social media to reach all corners of the CMCRC community and out to the broader research community. The CMCRC Consortium-wide Coordinating Center will follow procedures it has established and is using for other NIH- supported coordinating centers to perform administrative tasks necessary to conduct consortium meetings and conference calls, prepare agendas and minutes, administer funds for training and education and support a web site for communications, transmission of data, information and descriptions of methods (e.g., protocols) and requests for reagents, biomaterials and (animal) models to be shared. Our proposal is both highly efficient and innovative because of the expertise and experience of our investigators, the uninterruptable nature of their backup for each other and the uninterruptable nature of the systems we will extend and update from the PCBC and PCTC to the CMCRC. The channeling of resources to translational research, basic research necessary to support translational research and the extension of our infrastructure through social media will be substantial.