Clinical Core

项目摘要 拟议的狼疮研究中心将利用将应用的广泛技术 监控推动患者疾病活动的分子通路，朝着个性化的最终目标迈进 治疗的方法。该项目的累积工作将生成一个无价的样本库，作为 为拟议的研究和未来的实验问题提供资源。因此，必要和重要的 临床核心的使命是确保所有患者都有全面的临床评估，并 患者样本和临床数据将被系统地编目和跟踪，充分存储，并 适当地传播。 这一核心将产生于德克萨斯大学西南分校儿童健康儿科风湿病学部 医疗中心(UTSW)和俄亥俄大学(NCH)的全国儿童医院，并利用 提供具有良好特征的儿童系统性红斑狼疮患者的样本，这些患者在生命早期就表现出疾病，通常 表现出极端的表型，缺乏混淆表型的共病。通过以下途径获得的血液样本 这一临床部分将作为整个拟议中心的儿科患者样本来源。 狼疮研究中心。 临床核心将建立在现有优势的基础上，并扩大到协调样本和数据采集， 处理、存储和分发此P50拨款提案。核心将利用历史悠久的 帕斯夸尔博士和赖特博士之间的合作，并将合作扩展到Ardoin博士，以扩大 核心的能力和优秀的组织发展起来，以联系临床和研究实验室。 这些策略和优势将使拟建的狼疮研究中心的科学家能够从不同的角度 各机构无缝协作，并允许研究人员跟踪相关的临床和实验室数据 以样本确保科学合理的相关研究，并促进真正的协同计划。

Project Summary The proposed Center for Lupus Research will take advantage of a wide range of technologies that will be applied to monitor molecular pathways driving disease activity in patients toward the ultimate goal of a personalized approach to therapy. Cumulative efforts from this project will generate an invaluable sample repository as a resource both for the proposed studies and future experimental questions. Thus, the necessary and important mission of the Clinical Core is to ensure that all patients will have a comprehensive clinical assessment and that patient samples and clinical data will be systematically catalogued and tracked, adequately stored, and appropriately disseminated. This Core will arise from the Divisions of Pediatric Rheumatology at Children’s Health at UT Southwestern Medical Center (UTSW) and Nationwide Children’s Hospital at Ohio University (NCH) and take advantage of the availability of samples from well-characterized pediatric SLE patients, who manifest disease early in life, often present extreme phenotypes and lack co-morbidities that confound the phenotypes. Blood samples obtained via this Clinical Component will serve as the source of pediatric patient samples for the entire proposed Center for Lupus Research. The Clinical Core will build upon existing strengths and expand to coordinate sample and data acquisition, processing, storage, and distribution for this P50 grant proposal. The Core will capitalize on the long-standing collaboration between Drs. Pascual and Wright and extend the collaboration to Dr. Ardoin in order to expand the Core’s capabilities and the outstanding organization developed to liaise the clinic and the research laboratory. These strategies and strengths will enable scientists of the proposed Center for Lupus Research from different institutions to work together seamlessly and allow investigators to track clinical and laboratory data associated with samples to ensure scientifically sound correlative studies and facilitate a truly synergistic program.