Pilot Research Projects Core

试点研究项目核心(PrPC)的作用将是监督和帮助开发试点项目，以带来 耶鲁/NIDA神经蛋白质组中心的新研究人员，帮助鼓励我们的年轻研究人员 中心的实验室开始从事药物滥用研究，传播中心的核心 向尚未使用神经蛋白质组学的研究成瘾的神经生物学的研究人员提供技术 技术，扩大中心的技术能力。该中心极大地增加了 在耶鲁大学和其他7个机构使用蛋白质组学方法的研究人员，并已成为 药物成瘾生物学方面的蛋白质组学研究。在11-14年度批出的19个项目包括 已经产生了至少9份出版物、4份摘要、13份赠款和1份待批的赠款申请。此外, 这些获奖者中有5人已经进入了使用蛋白质组的独立职位 接近了。15年的4个奖项将扩大该中心的技术，并将产生新颖的 与成瘾和大脑功能相关的研究结果。在目标1中，我们将在这一成功的基础上再接再厉，征集新的飞行员 通过我们的网站、Twitter、电子邮件、EAB和NIDA计划官员提出建议。警监会将鼓励 建议应用核心提供的技术或开发新技术的应用程序。 申请将接受中心和非中心调查人员在药物滥用方面的专家 对启动神经蛋白质组学研究感兴趣，以及具有细胞和蛋白质组专业知识的非中心研究人员 神经信号的分子方面与启动物质神经蛋白质组学研究的兴趣 虐待。申请将接受研究生，博士后研究员和更高水平的研究 这些调查实验室的工作人员。在目前的提案中，我们包括了4个潜在的项目， 包括一项技术开发试点，该试点将与其他8项提案一起提交 如果此次续订获得资金，请进行竞争性审查。在目标2中，我们将继续有两个试点项目进行审查 耶鲁大学高级调查人员，包括试点项目核心主任，以及两名非耶鲁审查员， 他们中没有一个人与审查的提案存在利益冲突。对成功的飞行员使用类似的标准， 提交的提案将根据它们是否符合方案的核心任务进行评估，如 以及它们的整体科学价值。在目标3中，我们将评估和跟踪试点计划的成功情况， 通过分析出版物、演示文稿和赠款申请。在目标4中，每个获得资助的项目都将 由中心核心员工指导，该员工是要使用的技术方面的专家，并将提供培训 获奖者。此外，如果获奖者来自没有药物滥用经验的实验室 研究，他们将被指派一名在药物滥用研究方面经验丰富的中心调查员 将在适当的药物滥用模式和实验设计方面提供指导。

The role of the Pilot Research Project Core (PRPC) will be to oversee and help develop pilot projects that bring new investigators into the Yale/NIDA Neuroproteomics Center, help encourage young investigators in our Center's laboratories embark on careers in substance abuse research, disseminate the Center's core technologies to researchers investigating the neurobiology of addiction who are not yet using neuroproteomics technologies, and expand the technical abilities of the Center. The Center has greatly increased the pool of researchers using proteomic methods at Yale and 7 other institutions, and has become a national resource for proteomic studies of biological aspects of drug addiction. The 19 projects awarded in grant years 11-14 have already resulted in at least 9 publications, 4 abstracts, 13 grants and one pending grant application. In addition, 5 of these awardees already have gone on to independent positions where they are using proteomic approaches. The 4 awards in year 15 will expand the Center's technologies and also will result in novel findings relevant to addiction and brain function. In Aim 1, we will build on this success and solicit new pilot proposals via our web site, Twitter, emails, EAB, and NIDA program officials. The PRPC will encourage applications that propose to apply technologies available from the Cores or to develop new technologies. Applications will be accepted from Center and non-Center investigators expert in substance abuse with interests in initiating research in neuroproteomics, and non-Center investigators with expertise in cell and molecular aspects of neuronal signaling with interests in initiating neuroproteomics research on substance abuse. Applications will be accepted from graduate students, postdoctoral fellows and higher level research staff from these investigators' laboratories. In the current proposal, we have included 4 potential projects, including one Technology Development Pilot, which together with 8 other proposals would be submitted for competitive review if this renewal is funded. In Aim 2, we will continue to have pilot projects reviewed by two senior Yale investigators, including the Director of the Pilot Project Core, as well as two non-Yale reviewers, none of whom have a conflict of interest with the proposals reviewed. Using similar criteria to successful pilots, the submitted proposals will be evaluated based on whether they meet the core mission of the program, as well as on their overall scientific merit. In Aim 3, we will evaluate and track the success of the Pilot Program, through analysis of publications, presentations and grant applications. In Aim 4, each funded project will be mentored by a Center Core staff who is an expert in the technology to be used and who will provide training to the awardee. Further, if the awardee is from a laboratory that does not have experience in drug abuse research, they will be assigned a Center investigator who is highly experienced in drug abuse research who will provide guidance in appropriate models of substance abuse and in experimental design.