Biostatistics and Data Management Core

BDM核心摘要/摘要 生物统计和数据管理(BDM)核心将负责提供PPG4 具有广泛的统计和数据管理专业知识的项目和调查人员。这个 BDM Core将负责创建、维护和无缝集成所有收集的 PPG4中的数据(临床、影像、生物标志物)以及建议的统计分析 每个项目(相关性、线性回归、通径分析、纵向分析、高 维度关联)。BDM核心将与PPG4调查人员密切合作，并 为每个特定假设提供数据集和分析，并将为调查人员提供 可根据要求以易于与任何统计分析程序一起使用的格式提供数据集。这个 BDM Core将与成像生物标志物方法学(IBM)Core密切合作，以促进 有效传输原始和经过处理的PET和MR图像以及成像结果 (测量皮质厚度、区域体积和脑血管疾病负担) BDM核心可以提供数据分析以及解释和传播 与成像结果相关的关联。同样，BDM核心将促进整合 其他结果(不是高维度的)、认知、血液等从 其他岩心将被整合到数据库中并用于随后的分析。BDM核心 将举行每周核心会议，讨论数据库中的数据集成、数据请求、 分析计划以及出现的一般方法问题。BDM核心将提供 对学生、博士后研究员和教职员工进行数据分析方面的培训，重点是分析 在PPG中使用的方法。此外，业务需求管理核心将每月组织一次研讨会， 专注于为研究生和博士后提供指导目的的特定主题 在PPG4中。

BDM Core Summary/Abstract The Biostatistics and Data Management (BDM) Core will be responsible to provide PPG4 projects and investigators with a broad range of statistical and data management expertise. The BDM Core will be responsible for creating, maintaining and seamlessly integrating all collected data (clinical, imaging, biomarkers) in this PPG4, as well as the statistical analysis proposed for each project (correlations, linear regression, path analysis, longitudinal analysis, high- dimensional associations). The BDM core will closely work with the PPG4 Investigators and provide datasets and analysis for each specific hypothesis and will provide investigators with datasets upon request in a format that is easy to use with any statistical analysis program. The BDM Core will work closely with the Imaging Biomarkers Methodology (IBM) Core to facilitate the efficient transfer of raw and processed PET and MR images and imaging outcomes (measures of cortical thickness, regional volumes, and cerebrovascular disease burden) so that the BDM Core can provide data analysis as well as interpretation and dissemination of associations related to imaging outcomes. Similarly, the BDM core will facilitate the integration of the rest of the outcomes (that are not-high-dimensional), cognitive, blood, etc. collected from the other cores to be integrated in the database and used in subsequent analyses. BDM Core will hold weekly Core meetings to discuss data integration in the database, data requests, analysis plans as well as general methodology issues as they arise. The BDM Core will provide training to students, post-doctoral fellows, and faculty in data analysis with focus on analysis methods used in the PPG. In addition, the BDM core will organize monthly seminars with a focus on specific topics with instructional purposes for graduate students and postdocs involved in the PPG4.