EuroFAANG: A European infrastructure for farmed animal genotype to phenotype research

该提案描述了EuroFAANG（欧洲ANG基因组功能注释）基础设施的概念开发和概念化，以实现欧洲养殖动物物种的物种，品种和种群的基因型到表型（G2 P）研究的全部潜力。为了实现准确的G2 P预测，有必要能够将高度复杂的性状作为中间信息表型的集合进行细化和分类，这些表型沿着从基因组到细胞、生物体、环境、群体以及跨不同环境的整个级联。EuroFAANG基础设施的目标是简化陆地和水生养殖动物G2 P研究的跨学科能力的使用，并为欧洲利益相关者提供所有相关设施，专业知识和知识的跨国访问。这将解决在动物遗传资源、表型和育种以及动物健康领域将泛欧国家设施聚集在一起的需求，这被2021年ESFRI路线图确定为基础设施领域的一个差距。该提案建立在当前五个H2020 EuroFAANG项目（AQUA FAANG，BovReg，GENE-SWitCH，GEroIMO和RUMIGEN）提供的基础上，并与欧洲研究基础设施景观中现有的数据管理和动物农业基础设施相连接。参与的机构和组织在基础和应用养殖动物科学方面拥有世界领先的专业知识，并巩固了与欧洲养殖动物科学利益相关者的联系。该提案的成果将使研究基础设施的发展更好地协调一致，以促进欧洲和全球优秀的养殖动物科学和前沿G2 P研究。

This proposal describes concept development and conceptualisation of a EuroFAANG (European Functional Annotation of ANimal Genomes) infrastructure to realise the full potential of genotype to phenotype (G2P) research across species, breeds and populations of farmed animalspeciesin Europe. To achieve accurate G2P predictions, it is necessary to be able to refine and characterise highly complex traits as sets of intermediate informative phenotypes along the entire cascade from genome to cell, organism, environment, population and across different environments. The goal of the EuroFAANG infrastructure is to streamline use of interdisciplinary capabilities for G2P research in terrestrial and aquatic farmed animals and provide transnational access to all of the relevant facilities, expertise and knowledge to European stakeholders. This will address the need to bring together national facilities at the pan-European level in the field of animal genetic resources, phenotyping and breeding, and animal health, which was identified as a gap in the infrastructure landscape by the 2021 ESFRI Roadmap. The proposal builds on the foundation provided by the five current H2020 EuroFAANG projects, AQUA FAANG, BovReg, GENE-SWitCH, GEroIMO and RUMIGEN and connects with existing infrastructures for data management and animal agriculture in the European research infrastructure landscape. The institutions and organisations involved have world-leading expertise in fundamental and applied farmed animal science and consolidated established connections to European stakeholders in farmed animal science. The outcomes of this proposal will lead to better alignment of the development of the research infrastructures landscape for the advancement of excellent farmed animal science and frontier G2P research in Europe and globally.