Data Management and Statistical Core

项目总结/摘要-数据管理和统计核心 数据管理和统计核心将提供数据库和统计支助， 与所有马约阿尔茨海默病研究中心核心合作， 神经退行性疾病的区别核心成员带来了发展方面的专业知识， 实施和管理关系数据库和统计方法需要分析 这样的数据。数据核心将1）维护和优化容纳纵向数据的马约ADRC数据库 由Cores收集的临床、神经心理测量、神经病理学、成像和液体生物标志物数据。（二） 为核心提供数据管理支持，用于患者和生物样本跟踪、电子数据 捕获和数据提取3）促进与NACC、NCRAD和外部调查人员的数据共享，以及4） 为发展项目（由行政核心管理）提供统计支持， 研究设计和统计方法的受训人员（来自研究教育部分），并开发 新的统计方法，以提高对认知能力下降的多个变量的相互作用的理解。 Data Core是马约ADRC的核心，主要负责数据管理和数据分析 研究工作的组成部分。作为这项工作的一部分，数据核心积极参与招聘工作， 和保留研究参与者，将参与者数据纳入电子数据储存库， 在马约ADRC和其他研究小组之间交换参与者样本和数据，包括 国家阿尔茨海默氏症协调中心（NACC），以及研究数据的分析和出版。 数据管理和统计核心是马约反歧视委员会正常运作的关键。的 核心的数据库系统对于跟踪参与者的状态等活动至关重要， 跟进，准确存储和访问研究项目的数据，适当上传统一数据 设置（UDS）数据到NACC，并提取数据供研究人员在进行他们的活动时使用 调查事务所核心委员会的统计专业知识与马约亚洲发展与和解委员会具有类似的重要性，因为它对以下方面至关重要： 准备数据进行分析，为具体的研究问题设计分析计划， 对研究数据进行适当的分析，并对研究结果进行最终解释。数据 管理和统计核心旨在合作推进对相似性的科学理解 和神经退行性疾病之间的差异通过它提供给马约ADRC的资源。

PROJECT SUMMARY/ABSTRACT – DATA MANAGEMENT AND STATISTICAL CORE The Data Management and Statistical Core will provide database and statistical support and collaboration to all Mayo Alzheimer's Disease Research Center Cores in the investigation of similarities and differences among neurodegenerative diseases. The members of the Core bring expertise in the development, implementation and management of relational databases and in the statistical methods needed to analyze such data. The Data Core will 1) maintain and optimize the Mayo ADRC database housing the longitudinal clinical, neuropsychometric, neuropathological, imaging and fluid biomarker data gathered by the Cores. 2) provide data management support to the Cores for patient and biological sample tracking, electronic data capture and data extraction 3) facilitate data sharing with the NACC, NCRAD and external investigators and 4) provide statistical support to the Development Projects (administered by the Administrative Core), to mentor trainees (from the Research Education Component) in study design and statistical methods, and to develop new statistical methods to improve understanding of the interactions of multiple variables on cognitive decline. The Data Core plays a key role of the Mayo ADRC, focusing on the data management and data analysis components of the research effort. As part of this effort, the Data Core is actively involved in the recruitment and retention of study participants, the incorporation of participant data into electronic data repositories, the exchange of participant samples and data within the Mayo ADRC and among other research groups, including the National Alzheimer's Coordinating Center (NACC), and in the analysis and of publication of research data. The Data Management and Statistical Core is essential to the proper functioning of the Mayo ADRC. The database systems of the Core are essential to activities including tracking participants' status for longitudinal follow-up, accurately storing and accessing data for research projects, appropriately uploading Uniform Data Set (UDS) data to NACC, and extracting data for the use of researchers in the conduct of their active investigations. The statistical expertise of the Core is of similar importance to the Mayo ADRC, as it is critical to the preparation of data for analysis, the design of analytical plans for specific research questions, the appropriate analysis of research data, and the final interpretation of the research findings. The Data Management and Statistical Core aims to collaborate in advancing the scientific understanding of similarities and differences among neurodegenerative diseases through the resources it provides to the Mayo ADRC.