Behavior and Circuitry of Directed Orofacial Exploration

摘要-研究项目2 定向口腔探查的行为和回路(马丁·德谢恩斯，带头人；大卫·克莱菲尔德) 该研究项目考虑感知问题以及控制电路的反向工程 触觉设置点的位置，即触觉的平均位置。控制可能发生在多个层面上。我们 重点关注两个层面的电路。一个层次的回路包括脑干和中脑内的通路。 初步数据显示可能累及Kölliker-Fuse核和上丘 运动前区域。第二层回路由下行的感觉和运动皮质通路组成。 这两个层次的电路的作用也将被研究与偏转和节律运动的关系。 鼻子。从运动皮质到触觉运动的自上而下的输入，可能还有鼻子运动，脑干的区域 可能与舌头的运动皮质控制同源(项目3)。这些数据显示在“接线图”上。 运动前通路和前2运动通路的“信号通路”。 我们进一步考虑在开放的竞技场中协调口腔面部动作。老鼠探索一种新的 使用动物缓慢增加其覆盖率和维度的测试的环境 搜索。留置传感器和记录电子设备将使我们能够监控不同运动动作的协调 在动物觅食的同时。 这些数据提供了一组限制口腔面部激活和操作的模型的连接 探索性电路。它们让我们深入了解自然界在网络设计中做出的运营权衡。 这些数据，以及来自研究项目1和3的补充解剖学和电生理学数据， 作为研究项目5的一部分进行分析，为口面部回路探索的理论分析提供输入 (项目4)。

Abstract - Research Project 2 Behavior and circuitry of directed orofacial exploration (Martin Deschênes, lead; David Kleinfeld) This Research Project considers perceptual issues along with reverse engineering of circuits for the control of vibrissa set-point, i.e., the mean position of the vibrissae. Control may occur on a multitude of levels. We focus on circuits at two levels. One level of circuitry comprises pathways within the brainstem and midbrain. Preliminary data suggests involvement of the Kölliker-Fuse nucleus and the superior colliculus as candidate premotor regions. A second level of circuitry is comprised of descending sensory and motor cortical pathways. The role of these two levels of circuitry will also be studied in relation to deflection and rhythmic motion of the nose. The top-down input from motor cortex to the vibrissa motor, and possibly nose motor, areas of brainstem may be homologous to motor cortex control of the tongue (Project 3). These data bear on the "Wiring diagram" and "Signal pathways" for premotor and pre2motor pathways. We further consider the coordination of orofacial actions in an open arena. Mice explore a novel environment using an assay in which the animal slowly increases both the coverage and dimensionality of its search. Indwelling sensors and logging electronics will allow us to monitor coordination across motor actions concurrent with the animals foraging. These data provide a set of connections that constrain models for the activation and operation of orofacial exploratory circuitry. They give insight into the operational tradeoffs that nature has made in network design. These data, along with complementary anatomy and electrophysiology data from Research Projects 1 and 3, analyzed as part of Research Project 5, provide input for a theoretical analysis of orofacial circuitry exploration (Project 4).