Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity

小胶质细胞是大脑的免疫细胞，已知对神经系统的感染性和非感染性损伤有反应。本项目旨在利用斑马鱼透明的、基因可适应的大脑，通过对大脑细胞成分（神经元、胶质细胞、小胶质细胞、血管、突触）的可视化，以及对突触密度的遗传操纵，以及对小胶质细胞在这一过程中的实时观察，在完整的、有行为的动物的单细胞水平上探索小胶质细胞的新功能。

Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. This project aims to use the transparent and genetically amenable brain of the zebrafish, to explore new functions of microglia at the single cell level in the intact, behaving animal, through visualization of cellular components of the brain (neurons, glia, microglia, blood vessels, synapses), and through the genetic manipulation of synaptic density, and real time observation of microglia in the process.