A Vevo 3100 Small Animal Ultrasound Machine for the University of Cincinnati

项目名称：辛辛那提大学Vevo 3100小型动物超声仪 项目摘要/摘要 目前的提案要求为升级我们的Visualsonics Vevo 2100小动物超声波提供资金 机器改装为Vevo 3100系统，将在辛辛那提大学心肺和 血管研究所。该系统将支持美国国立卫生研究院资助的辛辛那提大学研究社区 从心脏、主动脉和肺的心血管研究领域的广泛的研究人员 肾脏疾病和肿瘤学。小鼠的心率极快，因此必须使用高框 速度和超高频传感器能够快速和高分辨率图像采集， 因此，用于人类临床护理和研究的商业超声心动图系统不容易 适用于提供详细评估心脏解剖结构所需的时间和空间分辨率 并在小鼠身上发挥作用。在购买我们的原型机时(2010年6月)，Vevo 2100系统 代表了小动物超声心动图和超声波应用中的最先进技术 对于我们的研究人员在其实验应用中实现活体测量至关重要，并已 在过去的11年里，出版了60多种出版物。重要的是，收购Vevo 3100系统 将通过减少斑点噪声和伪影显著改善图像质量，从而实现更准确 和可重复性的测量，引入了4D成像，提供了更准确的功能心脏 测量，并允许更快的超声心动图(ECG)门控千赫兹可视化或EKV，允许 提高了时间和空间分辨率。此外，Vevo 2100已收到来自 从2023年12月起，Visualsonics Corporation将不再进行维护、服务或维修。AS 因此，要求升级到Vevo 3100以保持动物研究中体内分析的高水平 在辛辛那提大学，这对医学校园里的数十名调查人员至关重要，并向 该大学的其他150名由NIH资助的研究人员每年提供超过1.8亿美元的NIH支持。 我们要求的系统将由一位在小型计算机系统的各个方面拥有12年经验的博士科学家操作 动物超声和这台机器是由辛辛那提大学全力支持的，以支付 服务合同和技术开发，以帮助最大限度地减少向调查人员提供服务的直接成本。 总之，拟议使用这一工具将支持和加强现有和未来由美国国立卫生研究院资助的项目 并为未来的研究项目带来了新的研究方向。

Project Title: A Vevo 3100 Small Animal Ultrasound Machine for the University of Cincinnati PROJECT SUMMARY/ABSTRACT The current proposal requests funding for upgrading our VisualSonics Vevo 2100 small animal ultrasound machine to a Vevo 3100 system, to be housed and used in the University of Cincinnati Heart, Lung, and Vascular Institute. This system will support the NIH-funded research community at the University of Cincinnati spanning a broad range of investigators from the fields of cardiovascular research in the heart and aorta, lung and kidney diseases, and oncology. The extremely fast heart rate in mice necessitates the use of high frame rates and exceptionally high frequency transducers capable of rapid and high-resolution image acquisition, thus commercially available echocardiography systems for human clinical care and research cannot readily be adapted to provide the temporal and spatial resolution required for detailed assessment of cardiac anatomy and function in mice. At the time of purchase for our original machine (June 2010), the Vevo 2100 system represented the state-of-the-art technology in small animal echocardiography and ultrasound applications that were critical for our researchers to achieve in vivo measurements in their experimental applications and has resulted in more than 60 publications over the last 11 years. Importantly, acquisition of the Vevo 3100 system will markedly improve image quality via the reduction of speckle noise and artifacts allowing for more accurate and reproducible measurements, introduce 4D imaging providing more accurate functional cardiac measurements, and allow faster echocardiography (ECG)-gated kilohertz visualization or EKV, allowing for increased temporal and spatial resolution. Moreover, the Vevo 2100 has received an end-of-life notice from the VisualSonics Corporation and will no longer be maintained, serviced, or repaired as of December 2023. As such, the upgrade to the Vevo 3100 is requested to maintain the high level of in vivo analytics in animal studies at the University of Cincinnati, which are critical to dozens of investigators on the medical campus and open to the University’s other 150 NIH-funded investigators with upwards of 180 million dollars of NIH support annually. Our requested system will be operated by a Ph.D. scientist with 12 years’ experience in all aspects of small animal ultrasonography and this machine is fully supported by the University of Cincinnati to cover the cost of service contracts and technology development to help minimize the direct cost of services to the investigators. Together, proposed use of this instrument will support and enhance existing and future NIH-funded projects and lead to new directions of research for future projects.