Active Help, Immune Function and Health Outcomes in Alzheimer's Caregivers

该提案使用生态瞬时评估(EMA)方法来检查 如何为阿尔茨海默病患者及相关患者提供积极帮助 痴呆症(ADRD)会影响ADRD照顾者的免疫系统和健康。 我们假设，在情感上与受照者关系密切的照顾者将 显示免疫系统生物标志物的改善，自我报告的健康结果， 以及与健康相关的生活质量，因为他们的积极帮助增加了。二百多元 将从阿尔茨海默氏症卓越中心招募50名照顾者 长岛疾病中心参与一项三波纵向研究，在该研究中，我们 将在基线、6个月和12个月收集数据。我们将使用EMA方法来 在基线和6个月时收集有关积极帮助和照料环境的数据，以及 我们将评估免疫系统活动和自我报告的健康结果 基线、6个月和12个月。我们的分析将测试主动帮助是否 有益于炎症标志物(如IL-6/肿瘤坏死因子α受体) 和修复(例如，超氧化物歧化酶、黄体酮)在情感上感到亲近的照顾者中 收件人。

This proposal uses ecological momentary assessment (EMA) methods to examine how the provision of active help to individuals with Alzheimer’s Disease and related dementias (ADRD) influences the immune system and health of ADRD caregivers. We hypothesize that caregivers who feel emotionally close to the care recipient will show improvements in immune system biomarkers, self-reported health outcomes, and health-related quality of life as their active help increases. Two hundred and fifty caregivers will be recruited from the Center of Excellence for Alzheimer’s Disease of Long Island to participate in a three-wave longitudinal study in which we will collect data at baseline, 6 months, and 12 months. We will use EMA methods to collect data on active help and the caregiving context at baseline and 6 months, and and we will assess immune system activity and self-reported health outcomes at baseline, 6 months, and 12 months. Our analyses will test whether active help is beneficially associated with makers of inflammation (e.g., Il-6/TnF alpha-receptor) and repair (e.g., SOD, progesterone) among caregivers who feel emotionally close to the recipient.