Core A - Biospecimen Processing.

摘要 生物样本处理核心（BPC，核心A）的目标是提供高质量的临床注释 生物标本的所有五个研究项目在这个孢子应用程序以及正在进行和未来的孢子- 赞助DRP和CEP项目，并作为一个无与伦比的生物标本资源，以更广泛的 癌症研究社区。BPC将负责识别和招募每位患者 转诊至Siteman癌症中心的新诊断和复发性血液恶性肿瘤（不包括 多发性骨髓瘤）。这些患者的生物标本将通过利用 Siteman癌症中心组织采购核心（TPC）的广泛基础设施， 拥有超过15年的生物标本库经验。将收集临床数据 前瞻性地通过与现有临床数据库核心（CDC）集成并扩展其使命， 之前作为AML基因组学（GAML）计划项目的一部分建立，作为 研究与MDS和AML发病机制相关的基因突变。因此，核心A将 继续补充癌症中心的资源，集中专业知识和努力，全面收集， 注释、质量审查和分发专门用于转化性白血病和白血病的生物标本- 相关癌症研究。具体目标包括： 具体目标1。提供生物库和临床注释方面的专业知识，以专门支持项目1- 5在这个应用程序中。 具体目标2。提供持续的、高质量的、临床注释的生物标本资源， 血液恶性肿瘤患者生物标本，用于其他转化研究项目， 在这个SPORE程序之外。 具体目标3：制定一个全面和透明的计划，对收集的生物标本进行编目， 促进其分发给更广泛的血液学恶性肿瘤研究者的科学界。

ABSTRACT The goal of the Biospecimen Processing Core (BPC, Core A) is to provide high-quality, clinically annotated biospecimens to all five research projects in this SPORE application as well as ongoing and future SPORE- sponsored DRP and CEP projects, and to serve as an unparalleled biospecimen resource to the broader cancer research community. The BPC will be responsible for the identification and enrollment of every patient referred to the Siteman Cancer Center with newly diagnosed and relapsed hematologic malignancy (excluding multiple myeloma). Biospecimens from these patients will be collected, processed, and stored by leveraging the extensive infrastructure of the Siteman Cancer Center Tissue Procurement Core (TPC), a CAP-accredited biorepository with over 15 years of experience in biospecimen banking. Clinical data will be collected prospectively by integrating with and extending the mission of an existing Clinical Database Core (CDC), previously established as part of the Genomics of AML (GAML) Program Project to serve as a platform for the investigation of genetic mutations associated with the pathogenesis of MDS and AML. As such, Core A will continue to supplement Cancer Center resources with focused expertise and effort to comprehensively collect, annotate, quality review, and distribute biospecimens specifically for translational leukemia and leukemia- related cancer research. Specific Aims include: Specific Aim 1. To provide expertise in biobanking and clinical annotation to specifically support projects 1- 5 in this SPORE application. Specific Aim 2. To provide an on-going, high quality, clinically annotated biospecimen resource of hematological malignancy patient biospecimens for other translational research projects both within and external to this SPORE program. Specific Aim 3: To create a comprehensive and transparent plan to catalog collected biospecimens and facilitate their distribution to the broader scientific community of hematologic malignancy investigators.