Real time Dual Laser Raman Reactor Analyser with Probe for key inorganic nutrients inside Microalgae Bioreactors

生物反应器广泛应用于各种工艺，例如；食品和食品配料、化学品和药物化合物。这些生物反应器的监测使用了广泛的特定分析技术，这些技术通常需要采样，或者它们只是特定于单个参数。分析优化流程所需的因素是一个漫长而耗时的过程。在某些情况下，必须使用有害试剂进行分析。市场感兴趣的是在线，操作简单，免采样，自动分析技术，实时监测反应器内过程的性能。与使用单一通道设置相比，能够使用两个激光波长的拉曼光谱将允许更容易和有效地定制用于监测更广泛反应的化学计量模型。反应器使用的优化，加上正确的营养物用量，将以更低的投入成本获得更高的产品产量。ELODIZ是一家专门提供基于光谱的分析解决方案的公司，它的目标是推出一种基于拉曼光谱的传感器，用于在线监测生物反应器上的营养物质。本项目的重点是通过单探针通过多通道双激光拉曼器件定量硝酸盐和磷酸盐。用最佳拉曼设置监测这些关键无机营养物质的浓度，可以优化它们的浓度，以保持理想产品成功形成的最佳水平。ELODIZ将与布鲁内尔大学合作，建立必要的化学计量模型，将光谱特征与反应堆系数联系起来。

Bioreactors are broadly used in a wide variety of process, such as; foods and food ingredients, chemicals and pharmaceutical compounds. These bioreactors are monitored using a wide range of specific analytical techniques which often requires sampling, or they are just specific to a single parameter. This is a lengthy and time-consuming procedure to analyse the required factors to optimise the process. In some cases, the use of hazardous reagents is necessary to perform the analysis.The market is interested in on-line, simple to operate, sampling free, automatic analytical techniques, to monitor the performance of the process within the reactor in real time. Being able to use two laser wavelengths for Raman spectroscopy will allow easy and efficient tailoring of the chemometric modelling used to monitor the reactor on a broader range of reactions than using a single channel setup.The optimisation of the reactor use, associated with the correct dosage of nutrients will lead to higher product yield at lower input cost. ELODIZ, a company specialised on providing analytical solutions based on spectroscopy, is targeting to introduce a sensor based on Raman Spectroscopy for online monitoring of nutrients on bioreactors. This project's focus specifically on the quantification of nitrates and phosphates by a multichannel dual laser Raman device via a single probe. Monitoring the concentration of these key inorganic nutrients with the optimal Raman setup, their concentration can be optimised to maintain an optimum level for the desired product to be successfully formed. ELODIZ will work with Brunel university to create the necessary chemometric models that correlate spectral signature with reactor coefficients.