Formulation and validation of Reducose as a functional food ingredient to reduce risk of metabolic disorders

Phynova是一家英国中小企业，应用尖端技术开发使用药用植物的功能性食品成分。Phynova公司开发了一种从白桑叶中提取的水提取物Reducose，它可以阻断小肠中的α -葡萄糖苷酶，使碳水化合物通过小肠而不被消化。临床试验已经证明，在食用含有糖和其他碳水化合物的食物后，还原糖可以降低血糖（BG），而且没有副作用。还原糖可将糖、淀粉和面包的血糖生成指数（GI）降至较低的GI水平（即<55）。这个项目的挑战是将Reducose重新配制成“ReducosePlus”，这样它就可以直接纳入食品制造商的产品线（面包、意大利面、即食食品、方便食品），而不影响食品的味道、物理特性，包括总重量（活性剂量250mg）。ReducosePlus有可能改变食品行业对碳水化合物问题的反应，并显著提高制造商提供低GI食品/膳食的能力，因为它消除了减少碳水化合物含量的大量重新配方的需要。

Phynova is a UK SME applying cutting-edge technology to develop functional food ingredients using medicinal plants. Phynova has developed Reducose, a water extract of white mulberry leaves, which blocks alpha-glucosidase in the small intestine, allowing carbohydrates to pass through undigested. Clinical trials have proven that Reducose lowers blood glucose (BG) after eating foods containing sugars and other carbohydrates, without side-effects. Reducose lowers the glycaemic index (GI) of sugar, starch, and bread to low GI levels (i.e. <55).The challenge in this project is to reformulate Reducose into "ReducosePlus" so it can be incorporated straight into food manufacturers' product lines (bread, pasta, ready meals, convenience foods) without affecting the flavour, physical properties of the food, including the overall weight (active dose 250mg). ReducosePlus has the potential to transform the food industry's response to the carbohydrate problem, and significantly improve the ability of manufacturers to offer low GI foods/meals as it removes the need for extensive reformulation involved in reducing carbohydrate content.