West Virginia University Stroke COBRE

项目概要/摘要 中风是美国人死亡的第五大原因，也是导致残疾的主要原因 并且开发有效的中风治疗仍然是迫切需要的。实验中风 核心（ESC）是西弗吉尼亚大学（WVU）中风CoBRE的基本核心， 提供独特的专业知识，并开发新的工具和中风动物模型，以提高 中风研究者的有效性。ESC的总体目标是提供专业知识， 培训、仪器和资源，以便将中风动物模型纳入 参加西弗吉尼亚大学中风科布雷的初级研究人员和 更大的西弗吉尼亚大学神经科学和心血管研究社区。四是提出具体 ESC的目标将有助于推动WVU中风科布雷成为卓越中心， 从而在CoBRE资助结束后实现可持续性。目标1：提供专门知识， 在啮齿动物模型中产生中风的仪器和资源。目标2：提供流程 用户可以通过该网站访问ESC的专业知识和资源。目标3：提供指导和 中风实验研究培训。目的4：开发新的动物模型，并实施一项 实验中风核心的可持续发展商业计划。实现这些具体目标将 为研究社区提供一个功能强大的ESC，并为CoBRE的过渡搭建桥梁- 将ESC转换为独立的核心设施。

Project summary/Abstract Stroke is the fifth leading cause of death and the leading cause of disability among Americans and developing effective treatments for stroke remains a pressing need. The Experimental Stroke Core (ESC) is an essential core for the West Virginia University (WVU) Stroke CoBRE that provides unique expertise and develops novel tools and stroke animal models to enhance the effectiveness of stroke researchers. The overall goal for the ESC is to provide the expertise, training, instrumentation, and resources for the incorporation of animal models of stroke into the research of junior investigators participating in the WVU Stroke CoBRE and researchers in the greater WVU neuroscience and cardiovascular research community. The four proposed specific aims of the ESC will help advance the WVU Stroke CoBRE to a Center of Excellence and, thereby, achieve sustainability after CoBRE funding ends. Aim 1: To provide the expertise, instrumentation and resources to produce strokes in rodent models. Aim 2: To provide processes by which users can access the ESC expertise and resources. Aim 3: To provide mentoring and training in experimental stroke research. Aim 4: To develop new animal models and implement a sustainability business plan for the Experimental Stroke Core. Achieving these specific aims will provide a highly functioning ESC for the research community and bridge a transition of CoBRE- supported-ESC to an independent core facility.