Intellectual and Developmental Disabilities Research Centers 2020

项目摘要/摘要 这个P50奖将继续支持智力和发展障碍研究中心 (IDDRC)，这是肯尼迪·克里格研究所(KKI)和约翰斯科学事业的核心 霍普金斯大学(JHU)30多年来-支持研究人员寻求了解、治疗和 改善智力和发育障碍的不利影响，并传播 对公众的发现，以达到预防的目标。国际数据和发展中心继续围绕五个核心进行组织： (1)管理；(2)临床翻译；(3)基因组学；(4)神经成像；以及(5)行为表型， 以及一个综合研究项目，考察睡眠、昼夜节律紊乱和大脑的作用 自闭症儿童的发育。 该中心的组织和核心结构与NICHD IDD的研究重点保持一致 分支机构，包括了解碘缺乏病的病因和复杂的并存；改进早期识别和 筛查；确定生物标志物和结果衡量标准；了解自然历史；以及翻译 从发现到治疗，最终到公共政策--所有这些都有预防的目标。该中心的 翻译科学主题围绕着从实验室到临床再到连续统一体的知识进步 社区。“为了与这些目标保持一致，该中心的目标是全面促进翻译科学 T4翻译的连续体。这一强调在整个中心都得到了应用，更重要的是 通过链接到研究所的UCEDD(马里兰州中心)，通过行政核心进行传播 发展障碍)和神经发育障碍(LAND)计划中的领导力教育。 该中心的目标是：(1)提供必要的基础设施、专业知识和服务，以促进和 促进IDD领域的跨学科研究；(2)充当机构间 建立和实施了针对缺碘研究的伙伴关系(包括国际发展与发展中心之间的伙伴关系)； (3)在缺碘领域内提供与科学研究有关的培训和技术援助机会； 以及(4)作为(地方和国家)科学发现的翻译和传播中心 与IDD相关，以实现告知(并最终塑造)公共政策的目标。

PROJECT SUMMARY/ABSTRACT This P50 award will continue to support the Intellectual and Developmental Disabilities Research Center (IDDRC), which has been central to the scientific enterprise at the Kennedy Krieger Institute (KKI) and Johns Hopkins University (JHU) for over 30 years—supporting investigators seeking to understand, treat and ameliorate the adverse impact of intellectual and developmental disabilities (IDD), and to disseminate discoveries to the public toward a goal of prevention. The IDDRC continues to be structured around five Cores: (1) Administrative; (2) Clinical Translational; (3) Genomics; (4) Neuroimaging; and, (5) Behavioral Phenotyping, as well an integrated Research Project examining the role of sleep, circadian dysfunction, and brain development in children with autism. The Center's organization and Core structure are aligned with the research priorities of the NICHD IDD branch, including understanding etiology and complex comorbidities of IDD; improving early identification and screening; identification of biomarkers and outcome measures; understanding natural history; and translation of discovery to treatment and, ultimately, to public policy—all with a goal of prevention. The Center's translational science theme centers on progressing knowledge along the continuum from “labs to clinics to communities.” In keeping with these goals, this Center's aims promote translational science along the full continuum of T4 translation. This emphasis is employed throughout the Center, with added importance on dissemination through the Administrative Core via links to the Institute's UCEDD (Maryland Center for Developmental Disabilities) and Leadership Education in Neurodevelopmental Disabilities (LEND) programs. The Center's aims are to: (1) provide infrastructure, expertise, and services necessary to promote and facilitate interdisciplinary research in the field of IDD; (2) act as the vehicle through which inter-institutional partnerships (including inter-IDDRC partnerships) addressing IDD research are developed and implemented; (3) provide training and technical assistance opportunities related to scientific inquiry within the field of IDD; and (4) serve as a hub (both locally and nationally) for translation and dissemination of scientific discoveries related to IDD toward the goal of informing (and ultimately shaping) public policy.