Administrative Core

慢性鼻窦炎综合研究项目2（CRISP 2）是一个综合项目， 流行病学家、耳鼻喉科专家、过敏症专家和免疫学家， 提出更好地了解疾病异质性的分子和细胞机制，以及这些机制如何影响疾病的发生。 机制转化为临床表型、自然史和长期结果。该计划侧重 特别注意无鼻息肉的CRS（CRSsNP），这是一种高度流行但尚不清楚的表型， 我们目前的理解。CRISP 2的另一个重点是批判性地评估 以及患者同时患有CRS和肺部疾病（如哮喘）的共病状况的后果 或支气管扩张。另一个主题是让我们更好地理解为什么女性比男性 对CRS的影响比男性更大。为了实现这些目标，调查人员组成的 CRISP 2研究团队已经创新了新的检测方法和方法，以进行发病机制的前沿研究， 流行病学，最重要的是，合并了这两个学科，将机制与症状联系起来， CRS的严重程度、病史和结局。 行政核心（核心A）的主要职能是提供行政支助 对于该计划的积极综合努力，促进沟通和数据共享，催化 出版物和工作结果的报告，确保慢性鼻窦炎综合治疗 研究计划-2（CRISP 2）促进有效的培训职能和组织咨询委员会， CRISP 2参与中心和研究者的定期会议。核心A还负责 为该计划准备进度报告，并监督各机构的监管合规性 和政府机构。核心A将在促进协同和高级协作方面发挥核心作用 节目中的互动。我们将这些职能和其他职能组织成以下具体目标：1. 为CRISP 2提供中央行政服务，包括监督资金分配、管理 行政办公室，促进预算，人事或科学方向发生的变化，监督 准备进度报告，并确保适当遵守NIH、NU、UC的指令， G/JHU和地方、州和联邦机构。管理团队为Schleimer博士（PI）、Valarie托马斯女士 以及Seletta Nichols女士（管理员）和Alfred Rademaker博士（生物统计学家）。2.）的情况。以促进 CRISP 2中的通信，并组织一个咨询委员会。CRISP 2将每季度举行四次会议， 2015年，将继续使用云通信系统。3.）第三章传播科学家的发现 CRISP2.核心项目A将协助编写文稿和维护网站。4.）鼓励培训。 核心A将支持一个正在进行的年轻学者赠款计划。5.）促进跨学科研究。 核心A将促进参与CRISP 2的学科和个体研究者之间的互动。

ABSTRACT The Chronic Rhinosinusitis Integrative Studies Program 2 (CRISP2) is an integrated program of epidemiologists, otolaryngologists, allergists and immunologists in which highly collaborative studies are proposed to better understand the molecular and cellular mechanisms of disease heterogeneity and how these mechanisms translate into clinical phenotypes, natural history and long term outcomes. The program focuses particular attention to CRS without nasal polyps (CRSsNP), a highly prevalent and yet obscure phenotype from the standpoint of our current understanding. Another focus of CRISP2 is to critically evaluate the mechanisms and consequences of comorbid conditions in which patients have both CRS and lung disease such as asthma or bronchiectasis. Yet another theme is to make inroads in our understanding of why women are more significantly impacted by CRS than men. In order to achieve these goals, the investigators that comprise the CRISP2 study team have innovated new assays and approaches to cutting edge studies of pathogenesis and epidemiology and, most importantly, have merged these two disciplines to relate mechanisms to symptoms, severity, history and outcomes of CRS. The Administrative Core (Core A) has as its main functions the goals of providing administrative support for the vigorous integrative efforts of the program, facilitating communication and data sharing, catalyzing publications and reporting of the findings of the work, ensuring that the Chronic Rhinosinusitis Integrative Research Program-2 (CRISP2) promotes an effective training function and organizing the advisory board and the regular meetings of the CRISP2 participating centers and investigators. Core A is also responsible for the preparation of progress reports for the program and overseeing regulatory compliance with various institutional and governmental agencies. Core A will play a central role in promoting synergy and advanced collaborative interactions in the program. We have organized these and other functions into the following specific aims: 1.) To provide central administrative services for CRISP2, including oversight of funds distribution, managing the administrative office, facilitating changes that occur in budget, personnel or scientific direction, overseeing preparation of progress reports and assurance of appropriate compliance with directives from the NIH, NU, UC, G/JHU and local, state and federal agencies. The administrative team is Dr. Schleimer (PI), Ms. Valarie Thomas and Ms. Seletta Nichols (administrators) and Dr. Alfred Rademaker (biostatistician). 2.) To facilitate communications in CRISP2 and organize an advisory board. CRISP2 will have four quarterly meetings each year and will maintain an internet-based cloud communications system. 3.) To disseminate discoveries made by CRISP2. Core A will facilitate manuscript preparation and maintenance of a website. 4.) To encourage training. Core A will support an ongoing grant program for young scholars. 5.) To promote interdisciplinary research. Core A will facilitate interactions of the disciplines and individual investigators that are involved in CRISP2.