Developmental Research Program (DRP)

摘要 使孢子研究人员能够迅速开发新的研究机会，这些机会可以转化为 乳腺癌患者的早期益处，并允许探索可能需要 我们付出了巨大的努力，但仍未准备好接受全面的多年研究资金，我们有 为这项孢子发育研究计划投入了大量的精力和资源。高管们 委员会与倡导者成员和内部咨询委员会一起挑选资助提案 作为发展项目，根据其科学价值和与孢子翻译目标的相关性。 通过对试点项目的资助，我们拓宽了研究范围，并允许探索高风险 在乳腺癌的治疗、预防或基础生物学方面有可能获得高收益的想法。我们也 吸引具有广泛专业知识的新调查人员将他们的专业知识应用于问题和 乳腺癌研究中的问题，我们催化富有成效的合作，在这种合作中，个人技能和 各种方法结合在一起，创造了任何单一的调查者无法单独取得的进展。指出这一点很重要 尽管每年只需要从孢子基金中为这个项目申请50,000美元，但贝勒学院 医学部每年额外捐助50,000美元，以表彰这项外展工作的价值 在贝勒做癌症研究。 自1992年我们的第一个乳孢子奖以来的26年里，我们资助了106个发展 项目，为128种出版物作出贡献，并为85项成功赠款提供必要的初步数据 有几个申请仍在审理中。本应用程序中的两个新的完整项目部分派生自 给张博士和威斯布鲁克博士的发展项目。这一机制补充了更大更长的- 定期定期研究项目，提供一定程度的灵活性，从而提高孢子的生产力 作为一个整体。

ABSTRACT To enable SPORE investigators to rapidly develop new research opportunities which could translate into early benefits for breast cancer patients, and to allow for exploration of new techniques which may require substantial efforts but which are nevertheless not ready for full scale multi-year research funding, we have devoted considerable effort and resources to this SPORE Developmental Research Program. The Executive Committee, together with the advocate members and the Internal Advisory Board, selects proposals for funding as Developmental Projects, based on their scientific merit and relevance to SPORE translational goals. Through the funding of pilot projects, we broaden the scope of research, and allow exploration of high-risk ideas that have the potential for high yields in treatment, prevention, or basic biology of breast cancer. We also attract new investigators with a wide variety of special expertise to apply their expertise to problems and questions in breast cancer research, and we catalyze productive collaborations in which individual skills and approaches combine to create progress that no single investigator could achieve alone. It is important to point out that, although only $50,000 per year is requested from SPORE funds for this program, and Baylor College of Medicine is contributing an additional $50,000 per year in recognition of the value of this outreach effort to cancer research at Baylor. During the 26 years of funding since our first Breast SPORE award in 1992, we funded 106 developmental projects, contributing to 128 publications and providing essential preliminary data for 85 successful grant applications with several still pending. Two of the new full projects in this application derived in part from developmental projects to Drs. Chang and Westbrook. This mechanism complements the larger and longer- term regular research projects, offering a degree of flexibility which leads to enhanced productivity for the SPORE as a whole.