FASEB SRC: The Consequences of Aneuploidy: Honoring the Contributions of Angelika Amon

摘要 我们正在为一个新的名为“非整倍体的后果： 向安吉丽卡·阿蒙的贡献致敬。本次大会将于2022年9月11日至16日举行， 在马萨诸塞州的南桥。这次会议的总体目标有两个：第一，汇聚 世界领先的专家研究非整倍体的后果，第二，表彰 安吉丽卡·阿蒙，非整倍体研究的先驱，于2020年死于卵巢癌。 非整倍体，或染色体拷贝数不是有机体正常的整数倍的状态 单倍体补体，是恶性生长的标志，也是智力最常见的遗传原因 残疾。目前基于测序的估计表明，高达90%的人类肿瘤表现出非整倍体，并且 高水平的非整倍体与转移性疾病、耐药性和令人沮丧的患者预后有关。 尽管非整倍体在癌症中无处不在及其对人类健康的意义，但没有规则的 在美国举行的会议致力于分享这类基因组改变的最新进展。 我们的目标是就这一主题建立一个新的会议，作为一个论坛，将科学家们聚集在一起分享 这一令人兴奋和快速发展的领域的最新进展。本次会议的组织团队由以下人员组成 领衔的非整倍体研究人员，他们是Angelika的同事和受训人员，并将召开这次就职典礼 是她记忆中的一次会议。这个团队已经获得了FASE B对这次会议的支持，它将 为活动提供重要的组织、后勤和技术支持。R13赠款资金正在 要求补贴职业生涯早期研究人员和任职人数不足的研究人员的费用 出席这次活动的背景。我们目前有41名确认演讲者，涉及10个主题领域，涉及 非整倍体和染色体分离，特别关注非整倍体对肿瘤的影响 发展与人类健康。还计划为职业生涯早期的科学家提供额外的编程，包括一系列 简短的演讲，两次海报会议，以及几次职业发展活动。

Abstract We are requesting grant support for a new FASEB conference entitled “The Consequences of Aneuploidy: Honoring the Contributions of Angelika Amon.” This conference will be held from September 11th to 16th, 2022, in Southbridge, Massachusetts. The broad goals for this conference are two-fold: first, to bring together the world’s leading experts in studying the consequences of aneuploidy, and second, to honor the contributions of Angelika Amon, a pioneer of aneuploidy research who passed away from ovarian cancer in 2020. Aneuploidy, or a chromosome copy number state that is not a whole-number multiple of an organism’s normal haploid complement, is a hallmark of malignant growth and is the most common genetic cause of intellectual disability. Current sequencing-based estimates suggest that up to 90% of human tumors exhibit aneuploidy, and high levels of aneuploidy are associated with metastatic disease, drug resistance, and dismal patient outcomes. Despite the ubiquity of aneuploidy in cancer and its significance to human health, there are no regular conferences in the United States dedicated to sharing the latest advances on this class of genomic alterations. We aim to establish a new conference on this topic that will serve as a forum to bring together scientists to share the latest advances in this exciting and fast-moving field. The organizing team for this conference consists of leading aneuploidy researchers who were Angelika’s colleagues and trainees and are convening this inaugural conference in her memory. This team has already secured the support of FASEB for this conference, which will provide significant organizational, logistic, and technical support for the event. R13 grant funding is being requested to subsidize the costs for early-career researchers and researchers from under-represented backgrounds to attend this event. We currently have 41 confirmed speakers across 10 topic areas related to aneuploidy and chromosome segregation, with a particular focus on the impact of aneuploidy on tumor development and human health. Additional programming is planned for early-career scientists, including a series of short talks, two poster sessions, and several career-development events.