Assessment of Fetal Alcohol Spectrum Disorders (FASD) Using Novel Web-Based Tools

产前酒精暴露的有害影响，包括认知、行为和身体影响， 几十年来都有很好的记录。它们包括对多个领域的长期影响 功能。受酒精影响的人通常不会被认出。此外，等待评估的时间可能会很长 长时间，进一步推迟了对受影响个人的准确识别。有效的在线筛查工具可以 缩短专科诊所的等待时间并简化评估。 产前酒精暴露仍然是一个重大的公共卫生问题，并在以下方面加大了努力 记录风险、改进识别和提供临床有效的工具是最重要的。因此， 这项提案的主要目的是改进产前酒精暴露和胎儿酒精的筛查 通过部署帮助临床评估的基于网络的工具来治疗谱系障碍(FASD)。两个主要工具将是 使用，FASD-树和个人神经行为的简要评估-在线版本(大脑-在线)。 这两个工具都使用基于Web的技术来收集数据，并向临床医生提供有关 个体的身体、行为和认知属性。具体地说，FASD-Tree记录物理和 行为数据，和大脑在线测量冲动，注意力，解决问题，处理速度， 记忆、空间工作记忆和定势转移。 为了达到这项研究的目的，将使用以下两种方法之一对6-17岁的儿童受试者进行评估 FASD-Tree和Brain-Online或单独Brain-Online(目标1-3)。家长将完成在线问卷调查 关于他们孩子的背景，人口统计和行为，一些孩子将被给予 标准化的面对面神经心理测试组件。在目标1中，我们将考察 FASD-Tree和Brain-Online，包括每个工具和 他们的组合。在目标2中，来自这些新工具的数据将与传统和先进相结合(例如， MorpheusQ和3D面部成像)通过其他CIFASD项目收集的物理测量。这个 建议的研究中使用的措施组合将产生方便、可扩展和经济高效的 作为标准诊断工具的附件。

The detrimental effects of prenatal alcohol exposure, including cognitive, behavioral, and physical impacts, have been well documented over several decades. They include long-standing effects on multiple domains of function. Alcohol-affected individuals often go unrecognized. In addition, wait times for evaluation can be quite long, further delaying the accurate identification of affected individuals. Effective online screening tools can decrease wait times and streamline evaluations in specialty clinics. Prenatal alcohol exposure continues to represent a significant public health concern and increased efforts at documenting risk, improving identification, and providing clinically-efficient tools are paramount. As such, the overarching aim of this proposal is to improve the screening for prenatal alcohol exposure and fetal alcohol spectrum disorder (FASD) by deploying web-based tools that aid in clinical evaluation. Two main tools will be used, the FASD-Tree and the Brief Assessment of Individual Neurobehavior – online version (BRAIN-online). Both tools use web-based technology for collecting data and provide the clinician with information about the individual’s physical, behavioral, and cognitive attributes. Specifically, the FASD-Tree records physical and behavioral data, and BRAIN-online measures impulsivity, attention, problem-solving, processing speed, memory, spatial working memory, and set-shifting. To achieve the aims of this study, child subjects (6-17y) will be evaluated using either the combination of FASD-Tree and BRAIN-online or BRAIN-online alone (Aim 1-3). Parents will complete online questionnaires regarding their child’s background, demographics, and behavior and some children will be given a standardized in-person neuropsychological test battery. In Aim 1, we will examine the relation between FASD-Tree and BRAIN-online, including classification accuracy, sensitivity, and specificity for each tool and their combination. In Aim 2, data from these novel tools will be combined with traditional and advanced (e.g., MorpheusQ and 3D facial imaging) physical measurements collected through other CIFASD projects. The combination of measures used in the proposed research will result in a convenient, scalable, and cost-effective adjunct to standard diagnostic tools.