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中文摘要
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项目摘要摘要:行政核心 行政核心是使MSCP孢子能够完成其使命和愿景的枢纽 当前黑色素瘤和其他皮肤癌治疗中的关键问题和障碍,以改善患者 结果。行政核心将提供科学和财政监督,并在以下方面加强沟通 多层次保证了MSCP孢子的成功。核心将监督日常运营, 协调定期的行政和科学审查,并与NCI项目办公室密切合作。堆芯 人员将与匹兹堡大学医学中心协调MSCP孢子活动 (UPMC)希尔曼癌症中心(HCC),其教职员工参与MSCP的部门和学校 孢子项目,与外部合作机构和倡导团体合作。核心将促进 孢子项目之间的相互作用以及与MSCP孢子区域外的相关研究的相互作用, 在国内和国际上。该核心将监督发展研究计划(DRP)和 职业提升计划(CEP),并就这些申请发出新的试点项目申请 以年度为基础,安排他们对DRP和CEP成功申请的审查、优先顺序和资金。 行政核心将提供行政框架,通过该框架,Spores将执行 委员会、内部咨询委员会(IAB)和外部咨询委员会(EAB)以及我们的患者权益倡导者 可以评估计划活动并根据需要重定向资源,以最大限度地提高翻译进度 MSCP孢子的目标。核心将致力于提高对黑色素瘤癌症的认识并增加 慈善支持黑色素瘤和皮肤癌研究,提升深度和广度 MSCP孢子研究工作的影响。将这些工作集中在核心部门可最大限度地提高效率 并确保孢子指南在整个程序中得到统一遵守。行政核心 将监测孢子研究项目和核心的预算,以确保不发生重复工作 在MSCP孢子和肝细胞癌的共享设施、肝细胞癌的其他资助孢子或国家 合作小组。核心将由三个研究项目平均使用,另外两个核心, DRP和CEP。
英文摘要
Project Summary Abstract: Administrative Core The Administrative Core is the hub that will enable the MSCP SPORE to fulfill its mission and vision to address key problems and barriers in current therapies for melanoma and other skin cancers, to improve patient outcomes. The Administrative Core will provide scientific and fiscal oversight and enhance communication on multiple levels to ensure the success of the MSCP SPORE. The Core will oversee day-to-day operations, coordinate periodic administrative and scientific reviews, and work closely with the NCI Program Office. Core personnel will coordinate MSCP SPORE activities with those of the University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center (HCC), the Departments and Schools whose faculty participate in MSCP SPORE projects, with outside collaborating institutions, and with advocacy groups. The Core will foster interactions among SPORE projects and with related research outside the MSCP SPORE regionally, nationally, and internationally. The Core will oversee the Developmental Research Program (DRP) and the Career Enhancement Program (CEP) and issue requests for new pilot project applications for these on a semi- annual basis, arranging for their review, prioritization, and funding of successful DRP and CEP applications. The Administrative Core will provide the administrative framework through which the SPORE Executive Committee, Internal Advisory Board (IAB), and External Advisory Board (EAB) as well as our patient advocates can evaluate program activities and redirect resources as needed to maximize translational progress toward the goals of the MSCP SPORE. The Core will work to raise melanoma cancer awareness and to increase philanthropic support of melanoma and skin cancer research, to enhance the depth and increase the breadth of impact of the MSCP SPORE research effort. Centralization of these efforts in the Core maximizes efficiency and ensures that SPORE guidelines are followed uniformly throughout the program. The Administrative Core will monitor budgets of the SPORE Research Projects and Cores to ensure that no duplication of effort occurs between the MSCP SPORE and the shared facilities at HCC, other funded SPOREs at HCC, or the national cooperative groups. The Core will be used equally by the three research projects, the other two Cores, the DRP, and the CEP.
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Project 2: Immunotherapy with CMP-001 intratumoral and nivolumab in melanoma
Administrative Core
Project 2: Immunotherapy with CMP-001 intratumoral and nivolumab in melanoma
Project 2: Immunotherapy with CMP-001 intratumoral and nivolumab in melanoma
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