Imaging/Histopathology (I/H) Core

项目摘要（成像/组织学） 17名视觉科学家（持有13项符合条件的NEI R 01赠款）申请持续资助， 其人员将支持新设立的三个资源/服务核心和一个行政核心， 合并眼科、视觉和解剖科学系（原眼科 和解剖学/细胞生物学部门）。将指导成像/组织学（I/H核心） Ryan Thummel博士，R 01资助的研究员，具有重要的成像专业知识。一起 与PI和两名研究助理，环境和能力进行愿景 韦恩州立大学及其附属机构的研究将通过以下方式得到加强 优先考虑NEI R 01资助的研究人员，他们的工作人员和学生（研究生和 研究员）在成像和组织病理学的许多方面。I/H核心，位于Scott Hall 并且视觉科学家很容易获得，将提供视觉功能分析，嵌入， 组织切片/冷冻切片和免疫染色，用于共聚焦激光扫描，光 显微镜、免疫荧光、OCT和其它细胞成像分析（例如，细胞活力和 质膜电位的定量）和设备使用培训。I/H核心将 促进NEI R 01资助的研究者之间的合作，主要是 没有资金的同事临床和转化研究也将在NEI R 01 资助新合并部门（OVAS）的研究人员和临床医生。I/H核心 将以较低的优先级支持新的研究者和/或其他人（例如，那些谁正在寻求 新的研究方向）或正在收集初步数据以供NEI R 01资助的人士 成绩.

Project Summary (Imaging/Histopathology) Continuing funds are requested by 17 vision scientists (holding 13 eligible NEI R01 grants) and their personnel to support three resource/service cores and an administrative core in the newly merged Department of Ophthalmology, Visual and Anatomical Sciences (former Ophthalmology and Anatomy/Cell Biology Departments). The Imaging/Histopathology (I/H Core) will be directed by Dr. Ryan Thummel, an R01-funded investigator with significant imaging expertise. Together with the PI, and two research assistants, the environment and capability to conduct vision research at Wayne State University and affiliated institutions will be enhanced through prioritization of the work of NEI R01 funded investigators, their staff and students (graduate and fellows) in numerous aspects of Imaging and Histopathology. The I/H core, located in Scott Hall and readily accessible to vision scientists, will provide for visual function analysis, embedding, sectioning/cryosectioning and immunostaining of tissues, for confocal laser scanning, light microscopy, immunofluorescence, OCT and other cell imaging analyses (e.g., cell viability and quantification of plasma membrane potential), and train in equipment use. The I/H Core will foster collaboration among NEI R01 funded investigators primarily and at reduced priority for unfunded colleagues. Clinical and translational studies also will be fostered between NEI R01 funded investigators and clinicians in the newly merged department (OVAS). The I/H Core also will support, at reduced priority, new investigators, and/or others (e.g., those who are seeking new research directions) or who are collecting preliminary data to be used for NEI R01 grant submission.